胃溃疡是一种慢性疾病，影响着世界上约 10% 的人口。这种疾病是由压力、吸烟、饮酒、非甾体抗炎药（NSAID）、幽门螺杆菌感染和遗传因素等因素引起的。植物提取物等草药是新的药物来源，在治疗胃溃疡方面具有良好的效果。纳米技术和纳米医学在一定程度上已经能够实现这一目标。绿色合成是一种适用于化学和物理方法的替代方法。在过去的几年中，真菌、细菌、病毒、藻类和植物已被用来生产金属纳米颗粒。由于绿色方法合成的纳米颗粒可以有效地用于抗癌、抗糖尿病、抗溃疡、抗炎和抗氧化治疗，因此本综述的目的是研究绿色方法生产的金属纳米颗粒和金属氧化物对治疗以下疾病的效果：胃溃疡。为此，使用“胃溃疡和纳米颗粒”、“胃溃疡和绿色合成”等关键词组合对 PubMed、Scopus、Science Direct、Cochrane 数据库和 Google Scholar 中已发表的研究和评论文章进行电子检索。 “胃溃疡和纳米颗粒”。在对已发表的文章及其参考文献进行全面审查后，确定了 120 篇文章以供进一步详细审查。选取2000年至2023年3月期间的文章，并利用1972年和1997年发表的2篇文章。这项研究的结果表明，从植物中合成的聚合物、金属和金属氧化物纳米颗粒可以有效治疗胃溃疡，特别是由幽门螺杆菌、乙醇和 NSAID 引起的溃疡。© 2023。作者，下施普林格自然瑞士股份公司的独家许可。

Gastric ulcer is a chronic disease that affects about 10% of the world's population. This disease is caused by factors such as stress, smoking, alcohol consumption, nonsteroidal anti-inflammatory drugs (NSAIDs), Helicobacter pylori infection, and genetic factors. Herbal medicines such as plant extracts are new sources of drugs with promising results in treating gastric ulcers. Nanotechnology and nanomedicine have been able to reach this objective to some extent. Green synthesis is an alternative method adapted for chemical and physical methods. In the last few years, fungi, bacteria, viruses, algae, and plants have been used to produce metallic nanoparticles. Since nanoparticles synthesized by the green method can be effective in anticancer, antidiabetic, antiulcer, anti-inflammatory, and antioxidant treatments, the aim of this review was to study the effect of metal nanoparticles and metal oxides produced by the green method on the treatment of gastric ulcers. For this purpose, an electronic search of published research and review articles in PubMed, Scopus, Science Direct, Cochrane databases, and Google Scholar was conducted using a combination of keywords of "gastric ulcers and nanoparticles", "gastric ulcers and Green synthesis" and "stomach ulcers and nanoparticles". After a full review of published articles and their references, 120 articles were identified for further detailed review. The articles selected were between 2000 and March 2023, and 2 articles published in 1972 and 1997 were utilized. The results of this study have shown that polymeric, metal, and metal oxide nanoparticles synthesized from plants can be effective in treating gastric ulcers, especially ulcers caused by H. pylori, ethanol, and NSAIDs.© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.