癌症相关认知障碍（CRCI）与化疗后工作记忆相关区域的大脑激活改变有关。因此，提高工作记忆能力和相关的大脑激活可能有助于 CRCI 的恢复。在这项研究中，我们调查了基于正念的干预（MBI）对影响工作记忆相关大脑激活的潜力。报告认知问题的女性乳腺癌幸存者（N = 117）被随机分配到正念干预组（n = 43；MBI） 、体能训练（n=36；PT）或候补名单控制条件（n=38；WL）。参与者在干预前、干预后立即和干预后三个月完成了 MRI 扫描。基于任务的功能性 MRI 用于测量执行视觉-语言 n-back 任务时工作记忆相关大脑激活随时间变化的组间差异。包括 83 名参与者 (32/26/25 MBI/PT/WL) 的数据。与候补组相比，随着时间的推移，MBI 参与者的右中额叶和角回的任务相关激活减少，而右背后扣带皮层的激活增加。与体能训练组相比，随着时间的推移，MBI 参与者的双侧顶叶上小叶和右侧背侧前扣带皮层的大脑活动减少。体育训练和不干预之间没有发现差异。这项研究表明，为期 8 周的基于正念的干预可以显着改变执行工作记忆任务期间涉及工作记忆、注意力控制和情绪处理的大脑区域的大脑激活。这可能有助于 CRCI 的恢复。正念可能会在执行工作记忆任务时改变大脑激活模式，这最终可能有助于恢复更高阶的认知功能。© 2023。作者。

Cancer-related cognitive impairment (CRCI) has been associated with altered brain activation after chemotherapy in areas related to working memory. Hence, improving working memory capacity and associated brain activation might aid in the recovery of CRCI. In this study, we investigated the potential of a mindfulness-based intervention (MBI) to impact working memory-related brain activation.Female breast cancer survivors reporting cognitive complaints (N=117) were randomized into a mindfulness (n=43; MBI), physical training (n=36; PT), or waitlist control condition (n=38; WL). Participants completed MRI scans before the intervention, immediately after, and three months post-intervention. Task-based functional MRI was used to measure differences between groups over time in working memory-related brain activation while performing a visual-verbal n-back task.Data of 83 participants (32/26/25 MBI/PT/WL) was included. Compared to the waitlist group, MBI participants showed reduced task-related activation in the right middle frontal and angular gyrus and increased activation in the right dorsal posterior cingulate cortex over time. Compared to the physical training group, MBI participants showed reduced brain activation in the bilateral superior parietal lobule and right dorsal anterior cingulate cortex over time. No differences between physical training and no intervention were identified.This study showed that an 8-week mindfulness-based intervention can significantly alter brain activation across brain regions involved in working memory, attentional control, and emotion processing during performance of a working memory task. This might aid in the recovery of CRCI.Mindfulness might alter brain activation patterns while performing a working memory task, which might ultimately aid in restoring higher order cognitive functions.© 2023. The Author(s).