炎症相关的胰岛素抵抗是妊娠糖尿病（GDM）的关键触发因素，但其潜在机制和有效干预措施仍不清楚。在这里，我们报告了 GDM 患者胎盘炎症（肿瘤坏死因子-α）与母体葡萄糖代谢异常之间的关联，并且高发酵膳食纤维（HFDF；魔芋）可以通过肠道菌群短链脂肪酸减少 GDM 的发展-GDM小鼠模型中的胎盘炎症轴。从机制上讲，HFDF 增加了 Lachnospiraceae 和丁酸盐的丰度，通过增强肠道屏障和抑制细菌源性脂多糖的转移来减少胎盘源性炎症，并最终抵抗高脂饮食诱导的胰岛素抵抗。 Lachnospiraceae 和丁酸盐具有相似的抗 GDM 和抗胎盘炎症作用，并且它们可能通过抑制胎盘免疫功能障碍来改善胎盘功能和妊娠结局。这些发现表明重要的胎盘炎症相关机制参与了 GDM 的进展，以及 HFDF 通过肠道-菌群-胎盘轴降低 GDM 易感性的巨大潜力。

Inflammation-associated insulin resistance is a key trigger of gestational diabetes mellitus (GDM), but the underlying mechanisms and effective interventions remain unclear. Here, we report the association of placental inflammation (tumor necrosis factor-α) and abnormal maternal glucose metabolism in patients with GDM, and a high fermentable dietary fiber (HFDF; konjac) could reduce GDM development through gut flora-short-chain fatty acid-placental inflammation axis in GDM mouse model. Mechanistically, HFDF increases abundances of Lachnospiraceae and butyrate, reduces placental-derived inflammation by enhancing gut barrier and inhibiting the transfer of bacterial-derived lipopolysaccharide, and ultimately resists high-fat diet-induced insulin resistance. Lachnospiraceae and butyrate have similar anti-GDM and anti-placental inflammation effects, and they can ameliorate placental function and pregnancy outcome effects probably by dampening placental immune dysfunction. These findings demonstrate the involvement of important placental inflammation-related mechanisms in the progression of GDM and the great potential of HFDFs to reduce susceptibility to GDM through gut-flora-placenta axis.