糖尿病创面复杂的创面环境导致治疗效果不佳，炎症性疾病和血管损伤是此类患者死亡的主要原因。在此，受益于金属离子和寡糖的独特性质，专门开发了一种可喷雾、可控、适应性、pH响应的钼酸盐和寡糖纳米系统（CMO NPs）作为糖尿病伤口愈合的免疫调节和促进血管生成材料。 CMO NPs 表现出 Mo2 和寡糖 (COS) 的 pH 响应性释放，特别是对糖尿病伤口中观察到的碱性环境的响应。 CMO NP 通过显着刺激巨噬细胞线粒体功能来促进 M2 极化，从而提供抗炎环境。具体而言，一定浓度的CMO NPs会降低活性氧（ROS）和肿瘤坏死因子α（TNF-α）的表达，并上调线粒体膜电位（MMP）、超氧化物歧化酶（SOD）和白细胞介素10（IL-10）在巨噬细胞中表达。此外，CMO NPs 通过上调 PI3K/HIF-1α/VEGF 通路促进血管生成，这是形成新血管的关键过程，为愈合组织提供营养和氧气。值得注意的是，CMO NPs 促进了内皮细胞的细胞活力和迁移，并增强了血管生成基因（PI3K、AKT、HIF-1α、S6K、VEGF、PDGF-β、TGF-β）的表达。体外和体内研究表明，这种简单但强大的针对线粒体功能的纳米系统有潜力成为糖尿病伤口愈合的有效治疗方法。本文受版权保护。保留所有权利。本文受版权保护。版权所有。

The complex wound environment of diabetic wounds leads to poor treatment efficacy, and the inflammatory disorders and vascular injury are the primary causes of death in such patients. Herein, benefiting from the unique properties of metal ions and oligosaccharide, a sprayable, controllable, adaptive, pH-responsive nanosystem of molybdate and oligosaccharide (CMO NPs) was specially developed as an immunomodulatory and angiogenesis-promotion material for diabetic wound healing. CMO NPs exhibited pH-responsive release of Mo2+ and oligosaccharide (COS), specifically in response to the alkalescent environment observed in diabetic wounds. CMO NPs provided an anti-inflammatory environment by promoting M2 polarization through significantly stimulating macrophage mitochondrial function. Specifically, CMO NPs with a certain concentration reduced reactive oxygen species (ROS) and tumor necrosis factor α (TNF-α) expression, and upregulated mitochondrial membrane potential (MMP), superoxide dismutase (SOD), and interleukin 10 (IL-10) expression in macrophages. Moreover, CMO NPs facilitated angiogenesis via upregulating the PI3K/HIF-1α/VEGF pathway-a critical process for the formation of new blood vessels that supply nutrients and oxygen to the healing tissue. Remarkably, CMO NPs promoted cell viability and migration of endothelial cells, and enhanced the expression of angiogenic genes (PI3K, AKT, HIF-1α, S6K, VEGF, PDGF-β, TGF-β). In vitro and in vivo studies suggest this simple but powerful nanosystem targeting mitochondrial function has the potential to become an effective treatment for diabetic wound healing. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.