原发性晚期和复发性卵巢恶性肿瘤的大血管切除术以实现完全细胞减灭术:病例系列和文献系统回顾——突破血管肿瘤手术的界限。
Major vessel resection for complete cytoreduction in primary advanced and recurrent ovarian malignancies: A case series and systematic review of the literature - pushing the boundaries in oncovascular surgery.
发表日期:2023 Nov 01
作者:
Stefano Uccella, Mariachiara Bosco, Luca Mezzetto, Simone Garzon, Veronica Maggi, Simone Giacopuzzi, Alessandro Antonelli, Lucia Pinali, Pier Carlo Zorzato, Anna Festi, Enrico Polati, Stefania Montemezzi, Giovanni De Manzoni, Massimo P Franchi, Gian Franco Veraldi
来源:
GYNECOLOGIC ONCOLOGY
摘要:
肿瘤血管手术(切除癌症浸润的主要血管)具有挑战性,但可能是晚期卵巢癌患者实现完全细胞减灭术的关键。本研究的目的是回顾有关卵巢癌血管手术的文献,并报告在我们机构进行的所有病例的详细信息。我们回顾性回顾了在妇产科接受减瘤手术的卵巢癌患者的数据库维罗纳大学于 2021 年 1 月至 2023 年期间进行的研究。确定了在细胞减灭术期间至少切除一处主要血管的患者。然后,我们系统地回顾了从 Pubmed 和 Embase 开始到 2023 年 1 月检索的文献,报告了所有卵巢癌手术并伴有大血管切除术的病例。 5 名晚期/复发性卵巢癌患者在我们机构接受了大血管切除术。所有病例术前均发现血管受累,无一例发生意外损伤后行血管切除术。切除的主要血管为下腔静脉(n = 2)、髂总静脉(n = 2)、髂外动脉(n = 2)、左髂总动脉(n = 1)和左外动脉。髂静脉 (n = 1)。所有患者在血管切除前均接受了其他非妇科细胞减灭术并获得了 R0。三名 (60%) 患者经历了一种或多种术后并发症。经文献检索,共发现卵巢癌手术中大血管切除病例7例。分别有 2 例 (28.6%) 和 5 例 (72.4%) 病例切除了单根或多根主要血管。所有七名患者均接受了血管重建。四名(57.1%)患者报告术后并发症。总体而言,在最后一次随访时,12 名已确定的患者中有 66.7% 没有疾病 [中位时间 15.5 个月(范围 5-25)]。肿瘤血管手术对于选定的卵巢癌患者是可行的,前提是采用定制的多学科方法提供护理。版权所有 © 2023 作者。由爱思唯尔公司出版。保留所有权利。
Oncovascular surgery (the removal of major blood vessels infiltrated by cancer) is challenging but can be key to achieve complete cytoreduction in patient with advanced ovarian cancer. The aim of this study was to review the literature on oncovascular surgery in ovarian cancer and to report the details of all the cases performed at our institution.We retrospectively reviewed the database of ovarian cancer patients who underwent debulking surgery at the Department of Obstetrics and Gynecology of Verona University between January 2021 and 2023. Patients with at least one major vessel resection during cytoreduction were identified. We then systematically review the literature searching Pubmed and Embase from inception to January 2023 to report all cases of surgery for ovarian cancer with concomitant major vessel resection.Five patients with advanced/recurrent ovarian cancer underwent major vascular resection at our institution. Vascular involvement was preoperatively identified in all cases and no case of vascular resection was performed after accidental injury. The major vessels removed were the inferior vena cava (n = 2), the common iliac veins (n = 2), the external iliac arteries (n = 2), the left common iliac artery (n = 1), and the left external iliac vein (n = 1). All patients underwent other non-gynecological cytoreductive procedures prior to vessel removal and had R0 obtained. Three (60%) patients experienced one or more postoperative complications. The literature search identified a total of seven cases of major vessels resection in ovarian cancer surgery. A single or multiple major vessels were removed in two (28.6%) and five (72.4%) cases, respectively. All the seven patients underwent vascular reconstruction. Four (57.1%) patients reported postoperative complications. Overall, 66.7% of the 12 total identified patients were free from disease at the last follow-up [median 15.5 months (range 5-25)].Oncovascular surgery is feasible in selected patients with ovarian cancer, provided that a multidisciplinary approach with customized care is available.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.