表位碱基编辑：非恶性干细胞正在秘密进行。
Epitope base editing: Non-malignant stem cells are going undercover.
发表日期：2023 Nov 02
作者：
Shayan Saniei, Elvin Wagenblast
来源：
Cell Stem Cell
摘要：
工程造血干细胞可以免受靶向免疫治疗的影响。 Casirati 等人最近发表在《自然》杂志上。利用与急性髓性白血病和健康造血有关的表位的单碱基编辑来改变其抗体和嵌合抗原受体 (CAR) T 识别，同时保留其配体结合和酶功能。版权所有 © 2023 Elsevier Inc. 保留所有权利。
Engineered hematopoietic stem cells can be shielded from targeted immunotherapy. Recently published in Nature, Casirati et al. utilized single-base editing of epitopes implicated in acute myeloid leukemia and healthy hematopoiesis to alter their antibody and chimeric antigen receptor (CAR) T recognition while preserving their ligand binding and enzymatic function.Copyright © 2023 Elsevier Inc. All rights reserved.