干细胞作为一组未分化的细胞，具有丰富的自我更新能力和高增殖能力，作为治疗多种疾病的一种有前景的方法，近年来引起了许多研究人员的关注。然而，从细胞和分子的角度来看，DNA修复系统是通过干细胞技术实现治疗目标的最大挑战之一。 DNA修复机制对于不断增殖以应对各种类型的DNA损伤的干细胞来说是一个优势。然而，这种机制可以被认为是癌症干细胞的细胞存活和治疗抵抗游戏中的一张王牌，它可以阻碍各种类型癌症的治愈。因此，深入了解 DNA 修复系统可以使研究人员离实现主要治疗目标更近一步。 DNA修复系统的非凡之处在于，这个系统不仅受到遗传因素的控制，而且还受到表观遗传因素的控制。因此，有必要从两个方面研究DNA修复系统在维持癌症干细胞存活中的作用。© 2023。作者，获得Springer Nature Switzerland AG的独家许可。

Stem cells, as a group of undifferentiated cells, are enriched with self-renewal and high proliferative capacity, which have attracted the attention of many researchers as a promising approach in the treatment of many diseases over the past years. However, from the cellular and molecular point of view, the DNA repair system is one of the biggest challenges in achieving therapeutic goals through stem cell technology. DNA repair mechanisms are an advantage for stem cells that are constantly multiplying to deal with various types of DNA damage. However, this mechanism can be considered a trump card in the game of cell survival and treatment resistance in cancer stem cells, which can hinder the curability of various types of cancer. Therefore, getting a deep insight into the DNA repair system can bring researchers one step closer to achieving major therapeutic goals. The remarkable thing about the DNA repair system is that this system is not only under the control of genetic factors, but also under the control of epigenetic factors. Therefore, it is necessary to investigate the role of the DNA repair system in maintaining the survival of cancer stem cells from both aspects.© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.