肥大细胞 (MC) 在多种肿瘤中积累，包括黑色素瘤。虽然 MC 是感染和过敏性炎症中免疫的有效引发剂，但 MC 在抗黑色素瘤免疫中的功能尚不清楚。 MCs具有释放肿瘤细胞因子和蛋白酶、激活抗原呈递细胞并促进抗肿瘤适应性免疫的潜力。然而，在免疫抑制性肿瘤微环境 (TME) 中，MC 激活可能促进血管生成并有助于肿瘤生长。在这篇综述中，讨论了 MC 和黑色素瘤之间的关系，重点讨论了 TME 对 MC 激活的影响。版权所有 © 2023 Wolters Kluwer Health, Inc. 保留所有权利。

Mast cells (MCs) accumulate in a broad range of tumors, including melanomas. While MCs are potent initiators of immunity in infection, and in allergic inflammation, the function of MCs in anti-melanoma immunity is unclear. MCs have the potential to release tumoricidal cytokines and proteases, to activate antigen-presenting cells and to promote anti-tumor adaptive immunity. However, within the immunosuppressive tumor microenvironment (TME), MC activation may promote angiogenesis and contribute to tumor growth. In this review, the relationship between MCs and melanomas is discussed with a focus on the impact of the TME on MC activation.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.