皮肤黑色素瘤是一种高度侵袭性的皮肤肿瘤，其发病机制和进展具有复杂的信号通路的特点。尽管黑色素瘤的色素沉着程度决定其进展、转移和预后，但其与炎症细胞因子的关系仍不清楚。因此，我们评估了黑色素瘤色素沉着与血浆炎症细胞因子水平之间的关联。此外，我们研究了黑色素瘤主要解剖部位之间这种关系的潜在变化。我们招募了 2021 年 1 月至 2021 年 12 月期间到全南国立大学和顺医院就诊的皮肤黑色素瘤患者。黑色素瘤的解剖部位分为肢端部位和非肢端部位。使用计算机软件量化色素沉着程度。总共分析了九种炎症细胞因子，包括白介素（IL）-2、IL-4、IL-5、IL-10、IL-12、IL-13、粒细胞巨噬细胞集落刺激因子（GM-CSF）、干扰素-γ (IFN-γ) 和肿瘤坏死因子-α (TNF-α)。这项研究包括 80 名黑色素瘤患者。其中，53 人患有肢端黑色素瘤，27 人患有非肢端黑色素瘤。总体而言，IL-2、IL-4、IL-5、GM-CSF 和 IFN-γ 的血浆浓度与色素沉着减少显着相关。此外，在肢端黑色素瘤患者组中，IL-2、IL-4、IL-5、GM-CSF、IFN-γ和TNF-α的血浆浓度与色素沉着减少显着相关。我们的结果揭示了黑色素瘤色素沉着与各种细胞因子水平之间的显着关联，特别是在肢端黑色素瘤患者中；这些关联可能受到与肢端黑色素瘤相关的因素的影响，例如身体压力或创伤。这些相关性还可能为肢端黑色素瘤的治疗提供指导。版权所有 © 2023 Wolters Kluwer Health, Inc. 保留所有权利。

Cutaneous melanoma, a highly aggressive skin tumor, is characterized by complex signaling pathways in terms of its pathogenesis and progression. Although the degree of pigmentation in melanoma determines its progression, metastasis, and prognosis, its association with inflammatory cytokines remains unclear. Thus, we evaluated the associations between melanoma pigmentation and plasma levels of inflammatory cytokines; furthermore, we investigated the potential variations in this relationship across the primary anatomic sites of melanoma. We enrolled patients with cutaneous melanoma who visited Chonnam National University Hwasun Hospital between January 2021 and December 2021. The anatomical sites of melanoma were categorized as acral and non-acral sites. The degree of pigmentation was quantified using computer software. In total, nine inflammatory cytokines were analyzed, including interleukin (IL)-2, IL-4, IL-5, IL-10, IL-12, IL-13, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). This study included 80 melanoma patients. Of these, 53 had acral melanoma and 27 had non-acral melanoma. Overall, plasma concentrations of IL-2, IL-4, IL-5, GM-CSF, and IFN-γ demonstrated significant correlations with diminished pigmentation. Furthermore, in the acral melanoma patients group, plasma concentrations of IL-2, IL-4, IL-5, GM-CSF, IFN-γ, and TNF-α revealed significant correlations with diminished pigmentation. Our results reveal significant associations between melanoma pigmentation and various cytokine levels, particularly in acral melanoma patients; these associations can be influenced by factors related to acral melanoma, such as physical stress or trauma. These correlations may also provide directions for the treatment of acral melanoma.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.