通过评估符合和未达到世界卫生组织 (WHO) 关于体力活动、BMI 和吸烟建议的幸存者之间的 HRQoL 差异，探讨子宫内膜癌幸存者中可改变的生活方式因素与健康相关生活质量 (HRQoL) 之间可能存在的关联。这是一项基于人群的横断面研究，对象是接受过早期子宫内膜癌手术的女性。使用基于 EORTC QoL 工作组的临床重要性阈值来解释分数。效应大小 (ES) 被解释为小 (d = 0.2-0.49)、中 (d = 0.5-0.8) 和大 (d > 0.8)。总共包括 1200 名可评估女性。满足体力活动建议和 BMI <25 kg/m2 与显着改善的整体健康状况相关，分别为 (ES) = 0.18 和 ES = -0.11。在多变量分析中，达到身体活动建议的女性在身体（ES = 0.31）、角色（ES = 0.15）和社交功能（ES = 0.15）方面的得分显着较高，并且疲劳程度较低（ES = -0.16）与未见面的幸存者相比，疼痛（ES=-0.10）和食欲不振（ES=-0.15）（所有p<0.05）。与 BMI < 的参与者相比，BMI ≥ 25 kg/m2 的参与者的社会功能得分较低 (ES = -0.10)，疼痛 (ES = 0.13) 和呼吸困难 (ES = 0.12) 水平较高（全部 p < 0.05） 25 公斤/平方米。与非吸烟者相比，吸烟者的情绪功能得分较低 (ES = -0.09)，腹泻水平较高 (ES = 0.10)（均 p < 0.05）。符合世界卫生组织关于可改变生活方式因素的建议与改善 HRQoL 相关。子宫内膜癌幸存者：充分的体力活动和 BMI <25 kg/m2 与更好的自我报告的全球健康状况显着相关。所有可改变的因素都与更好的功能和减轻症状负担相关。版权所有 © 2023 作者。由爱思唯尔公司出版。保留所有权利。

To explore possible associations between modifiable lifestyle factors and health-related quality of life (HRQoL) in endometrial carcinoma survivors by assessing differences in HRQoL between survivors meeting and not meeting the World Health Organization's (WHO) recommendations regarding physical activity, BMI, and smoking.This was a cross-sectional population-based study in women having undergone surgery for assumed early-stage endometrial carcinoma. Thresholds for clinical importance based on the EORTC QoL working group were used to interpret scores. Effect size (ES) was interpreted as small (d = 0.2-0.49), medium (d = 0.5-0.8), and large (d > 0.8).In total, 1200 evaluable women were included. Meeting physical activity recommendations and BMI <25 kg/m2 was associated with significantly better global health status, (ES) = 0.18 and ES = -0.11, respectively. On multivariate analysis, women meeting physical activity recommendations had significantly higher scores on physical- (ES = 0.31), role- (ES = 0.15), and social functioning (ES = 0.15), and lower levels of fatigue (ES = -0.16), pain (ES = -0.10), and appetite loss (ES = -0.15) (all p < 0.05) compared to non-meeting survivors. Participants with BMI ≥25 kg/m2 had lower scores for social functioning (ES = -0.10), and higher levels of pain (ES = 0.13) and dyspnea (ES = 0.12) (all p < 0.05) compared to those with BMI <25 kg/m2. Smokers had lower scores for emotional functioning (ES = -0.09) and higher levels of diarrhea (ES = 0.10) (all p < 0.05) compared to non-smokers.Meeting WHO recommendations for modifiable life-style factors is associated with better HRQoL among endometrial carcinoma survivors: Being sufficiently physical active and having a BMI <25 kg/m2 are significantly associated with better self-reported global health status. All modifiable factors are associated with better functioning, and reduced symptom-burden.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.