酰胺质子转移（APT）成像已被提议作为评估肿瘤代谢的技术。然而，APT 成像与包括正电子发射断层扫描 (PET) 在内的其他定量模式之间的关系尚未得到详细研究。本研究旨在评估 APT 成像在确定恶性胶质瘤代谢状态方面的临床实用性，并将结果与​​ 11C-蛋氨酸 (Met)-PET 进行比较。本研究分析了 20 名连续接受治疗的恶性胶质瘤患者的 APT 成像数据。 2022年1月和2023年7月。患者接受了肿瘤切除术，并研究了肿瘤活性与APT信号强度之间的相关性。我们还比较了灶周肿瘤浸润区域相同区域的 11C-Met-PET 和 APT 成像。所有 20 例病例均获得了清晰的诊断性 APT 图像。胶质母细胞瘤 (GBM)、IDH 野生型组的平均 APT 强度 (APTmean) 显着高于其他胶质瘤组 (6.0±4.7%；p<0.001) (27.2±12.8%)。最佳区分 GBM 和其他恶性神经胶质瘤的 APTmean 截止值为 12.8%，敏感性为 100%，特异性为 83.3%。这些 APTmean 值与 11C-Met-PET 分析得出的肿瘤与对侧正常脑组织的比率大致匹配 (r = 0.66)。 T1加权成像中钆非造影区也观察到APT信号，似乎反映了周围肿瘤浸润区域。APT成像可用于评估肿瘤浸润区域，类似于11C-Met-PET。 APT 成像显示患者的侵袭性较低，有助于肿瘤切除的术前计划，有助于最大限度地切除肿瘤，包括肿瘤侵袭区域。© 2023。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Amide proton transfer (APT) imaging has been proposed as a technique to assess tumor metabolism. However, the relationship between APT imaging and other quantitative modalities including positron emission tomography (PET) has not been investigated in detail. This study aimed to evaluate the clinical usefulness of APT imaging in determining the metabolic status of malignant glioma and to compare findings with those from 11C-methionine (Met)-PET.This research analyzed APT imaging data from 20 consecutive patients with malignant glioma treated between January 2022 and July 2023. Patients underwent tumor resection and correlations between tumor activity and intensity of APT signal were investigated. We also compared 11C-Met-PET and APT imaging for the same regions of the perifocal tumor invasion area.Clear, diagnostic APT images were obtained from all 20 cases. Mean APT intensity (APTmean) was significantly higher in the glioblastoma (GBM), IDH wild type group (27.2 ± 12.8%) than in other gliomas (6.0 ± 4.7%; p < 0.001). The cut-off APTmean to optimally distinguish between GBM and other malignant gliomas was 12.8%, offering 100% sensitivity and 83.3% specificity. These values for APTmean broadly matched the tumor-to-contralateral normal brain tissue ratio from 11C-Met-PET analysis (r = 0.66). The APT signal was also observed in the gadolinium non-contrast region on T1-weighted imaging, appearing to reflect the surrounding tumor-infiltrated area.APT imaging can be used to evaluate the area of tumor invasion, similar to 11C-Met-PET. APT imaging revealed low invasiveness in patients and was useful in preoperative planning for tumor resection, facilitating maximum tumor resection including the tumor invasive area.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.