低血糖反复发作可能由多种因素引起，包括药物、危重疾病、激素缺乏、非胰岛细胞肿瘤内源性高胰岛素血症以及意外、秘密或恶意低血糖。此前已有多种药物被报道为低血糖的原因，证据质量为中度和低度。然而，氯吡格雷作为非糖尿病低血糖的原因很少有报道。在此，我们描述了一名非糖尿病患者，由于临床怀疑患有急性冠状动脉综合征，在开始服用氯吡格雷后，低血糖反复发作。该患者是一名 33 岁的埃塞俄比亚男性，在服用抗高血压药物期间有高血压记录，已开始接受以下治疗：出现心绞痛症状后出现急性冠状动脉综合征。开始服用氯吡格雷后，他出现了低血糖，但停药后血糖就消退了。目前，他在心脏诊所进行了随访，血清血糖水平正常。非糖尿病低血糖是一种罕见疾病，其特征是未患糖尿病的人血糖水平较低。严重低血糖的患者可能会因低血糖而失去意识或癫痫发作。严重低血糖是致命的，必须尽快治疗。因此，如果发生非糖尿病性低血糖，必须对原因进行彻底评估，特别是应评估任何可能导致低血糖的药物。© 2023。BioMed Central Ltd.，Springer Nature 旗下公司。

Recurrent episodes of hypoglycemia may be caused by several factors, including drugs, critical illnesses, hormonal deficiency, non-islet cell tumor endogenous hyperinsulinism, and accidental, surreptitious, or malicious hypoglycemia. Multiple drugs have been previously reported as causes of hypoglycemia, with moderate and low-quality evidence. However, Clopidogrel as a cause of non-diabetic hypoglycemia is rarely reported. Here we describe a single non-diabetic patient who experienced recurrent episodes of hypoglycemia after initiation of clopidogrel for clinical suspicion of acute coronary syndrome.The patient, a 33-year-old Ethiopian male with documented hypertension on antihypertensive medication, has started receiving treatment for acute coronary syndrome after experiencing angina symptoms. He experienced hypoglycemia following the start of Clopidogrel, but it subsided once it was stopped. Currently, he has a follow-up at the cardiac clinic with a normal measurement of his serum blood glucose level.Non-diabetic hypoglycemia is a rare illness characterized by low blood glucose levels in people who do not have diabetes. Patients with severe hypoglycemia may become unconscious or have seizures as a result of low blood sugar. Severe hypoglycemia is fatal and must be treated as soon as possible. Therefore, if non-diabetic hypoglycemia occurs, a thorough evaluation of the causes is essential, particularly any potential drug as a cause of hypoglycemia should be evaluated.© 2023. BioMed Central Ltd., part of Springer Nature.