在大量老年人群的实际实践中比较 IPI 和 PIT 对外周 T 细胞淋巴瘤的预后影响。
Comparison of the prognostic impact of IPI and PIT in peripheral T-cell lymphoma in real-world practice with a large elderly population.
发表日期:2023 Nov 04
作者:
Nobuhiko Nakamura, Nobuhiro Kanemura, Takuro Matsumoto, Hiroshi Nakamura, Yoshikazu Ikoma, Yuhei Shibata, Junnichi Kitagawa, Senji Kasahara, Toshiki Yamada, Michio Sawada, Yuto Kaneda, Kenji Fukuno, Eri Takada, Hideko Goto, Shin Lee, Kei Fujita, Tetsuji Morishita, Takeshi Hara, Hisashi Tsurumi, Masahito Shimizu
来源:
Disease Models & Mechanisms
摘要:
我们比较了国际预后指数 (IPI)(一种常用的外周 T 细胞淋巴瘤 (PTCL) 预后模型)与特定类型预后模型(PTCL-U 预后指数 (PIT))的预测能力。我们回顾性分析了 113 名诊断为 PTCL 的患者。中位年龄为 67 岁(范围为 16-88 岁),75 名患者(66%)为男性,最常见的疾病类型是 PTCL,未另有说明的(69%)。中位随访时间为 6.8 年(四分位距,2.7-9.9 年),IPI 四组的 5 年生存率分别为 85%、62%、49% 和 13%。同样,PIT 四组的 5 年生存率分别为 83%、64%、49% 和 19%。 PIT 预测死亡率的接收操作特征曲线下面积 (0.725) 与 IPI 预测死亡率的接收操作特征曲线下面积 (0.685, P = 0.134) 没有显着差异。多变量分析显示,体力状态≥2(P<0.0001)和结外病变≥2(P=0.029)与较低的总生存率显着相关。本研究发现 IPI 和 PIT 对 PTCL 的预后能力没有显着差异,并且这两种模型似乎都可用作预测模型。© 2023。作者。
We compared the predictive ability of the International Prognostic Index (IPI), a frequently used prognostic model for peripheral T-cell lymphoma (PTCL), with that of a type-specific prognostic model, the Prognostic Index for PTCL-U (PIT). We retrospectively analyzed 113 patients diagnosed with PTCL. The median age was 67 years (range, 16-88 years), 75 patients (66%) were male, and the most common disease type was PTCL, not otherwise specified (69%). With a median follow-up of 6.8 years (interquartile range, 2.7-9.9 years), 5-year survival rates for the four groups in IPI were 85%, 62%, 49%, and 13%, respectively. Similarly, 5-year survival rates for the four groups in PIT were 83%, 64%, 49%, and 19%, respectively. The area under the receiving operating characteristic curve for predicting mortality from PIT (0.725) was not significantly different from that from the IPI (0.685, P = 0.134). Multivariable analysis showed that performance status ≥ 2 (P < 0.0001) and extranodal lesions ≥ 2 (P = 0.029) were significantly associated with lower overall survival. The present study found no significant difference in prognostic ability between the IPI and PIT for PTCL, and both models appear useful as predictive models.© 2023. The Author(s).