TGFB1 编码 TGF-β1，这是一种有效的细胞因子，调节包括免疫反应在内的多种细胞过程。 TGF-β1 在癌症中发挥着背景依赖性作用，并且越来越多地被认为是增强免疫治疗反应的治疗靶点。我们全面评估了 TGFB1 的表达及其在血液恶性肿瘤中的临床和生物学效应。首先使用来自 GTEx、CCLE 和 TCGA 数据库的数据探索 TGFB1 表达。使用 Hemap 和我们的 In Silico 精选数据集分析了 TGFB1 在血液恶性肿瘤中的表达和临床意义。我们还分析了 Hemap 中 TGFB1 与免疫评分和免疫细胞浸润之间的关系。我们使用 TIDE 和真实世界免疫治疗数据集进一步评估了 TGFB1 在预测免疫治疗反应中的价值。 TGFB1 在正常组织和癌症类型中均显示出血液组织特异性表达模式。 TGFB1 表达在血癌中广泛失调，通常与不良预后相关。 TGFB1 表达与不同血癌类型中不同的 TME 特性相关。此外，TGFB1 表达被发现是预测免疫治疗反应的有用标记。我们的结果表明 TGFB1 在血液恶性肿瘤中广泛失调。 TGFB1 可能以癌症类型特异性的方式调节免疫微环境，可用于开发免疫治疗新靶向药物。© 2023。作者。

TGFB1, which encodes TGF-β1, a potent cytokine regulating varies cellular processes including immune responses. TGF-β1 plays context-dependent roles in cancers and is increasingly recognized as a therapeutic target to enhance immunotherapy responses. We comprehensively evaluated expression of TGFB1 and its clinical and biological effects across hematological malignancies. TGFB1 expression was first explored using data from the GTEx, CCLE, and TCGA databases. The expression and clinical significances of TGFB1 in hematological malignancies were analyzed using Hemap and our In Silico curated datasets. We also analyzed the relationship between TGFB1 with immune scores and immune cell infiltrations in Hemap. We further assessed the value of TGFB1 in predicting immunotherapy response using TIDE and real-world immunotherapy datasets. TGFB1 showed a hematologic-tissue-specific expression pattern both across normal tissues and cancer types. TGFB1 expression were broadly dysregulated in blood cancers and generally associated with adverse prognosis. TGFB1 expression were associated with distinct TME properties among different blood cancer types. In addition, TGFB1 expression was found to be a useful marker in predicting immunotherapy responses. Our results suggest that TGFB1 is broadly dysregulated in hematological malignancies. TGFB1 might regulate the immune microenvironment in a cancer-type-specific manner, which could be applied in the development of new targeted drugs for immunotherapy.© 2023. The Author(s).