目的 探讨对比增强乳腺摄影（CEM）成像特征与乳腺癌（BC）不同分子亚型之间的相关性。我们回顾性纳入2017年7月至2021年7月在我院接受CEM检查和手术的313例符合条件的女性患者。通过组织病理学检查和免疫组织化学分析证实病变。根据免疫组化标记，BC分为管腔A型、管腔B型、HER2富集型和三阴性BC（TNBC）亚型。从CEM图像中提取9个特征，包括肿瘤形状、边缘、针状肿块、分叶状肿块、恶性钙化、病灶明显、内部增强模式、多灶性肿块和腋窝淋巴结肿大。使用SPSS 25.0进行统计分析。采用单变量分析和二项回归分析CEM成像特征与BC分子亚型之间的相关性。Luminal A 184例（58.8%），Luminal B 44例（14.1%），HER-2富集47例（15.0%），HER-2富集38例。 (12.1%) TNBC 分别。分子亚型与肿瘤的形状、边缘、针状肿块、内部强化模式、恶性钙化和腋窝淋巴结肿大显着相关。针状和钙化肿瘤与 Luminal 亚型相关，尤其是 Luminal B (P < 0.05)。不规则的肿瘤形状和恶性钙化与 HER-2 富集亚型相关（P < 0.05）。椭圆形或圆形肿瘤形状、边缘强化和腋窝淋巴结肿大与 TNBC 相关（P < 0.05）。CEM 成像特征可以区分 BC 分子亚型。特别是，TNBC 显示椭圆形或圆形肿瘤形状、边缘强化和腋窝淋巴结肿大，为 TNBC 的诊断和预后提供了见解。版权所有 © 2023。由 Elsevier Ltd 出版。

To investigate the correlation between the contrast-enhanced mammography (CEM) imaging characteristics and different molecular subtypes of breast cancer (BC).We retrospectively included 313 eligible female patients who underwent CEM examination and surgery in our hospital from July 2017 to July 2021. Their lesions were confirmed on histopathological examination and immunohistochemical analysis. BC was divided into luminal A, luminal B, HER2-enriched, and triple-negative BC (TNBC) subtypes according to immunohistochemical markers. Nine features were extracted from CEM images, including tumor shape, margins, spiculated mass, lobulated mass, malignant calcification, lesion conspicuity, internal enhancement pattern, multifocal mass, and swollen axillary lymph nodes. Statistical analysis was performed using SPSS 25.0. Univariate analysis and binomial regression were used to analyze the correlation between CEM imaging features and BC molecular subtypes.There were 184 (58.8 %) Luminal A, 44 (14.1 %) Luminal B, 47 (15.0 %) HER-2-enriched and 38 (12.1 %) TNBC, respectively. Molecular subtypes were significantly related to the tumor shape, margins, spiculated mass, internal enhancement pattern, malignant calcification and swollen axillary lymph nodes. Spiculated and calcified tumors were associated with Luminal subtypes, especially Luminal B (P < 0.05). Irregular tumor shape and malignant calcification were associated with HER-2-enriched subtype (P < 0.05). Oval or round tumor shape, rim enhancement, and swollen axillary lymph nodes were associated with TNBC (P < 0.05).CEM imaging features could distinguish BC molecular subtypes. In particular, TNBC showed oval or round tumor shape, rim enhancement, and swollen axillary lymph nodes, providing insights into the diagnosis and prognosis of TNBC.Copyright © 2023. Published by Elsevier Ltd.