G-四链体 (G4) 引起了人们对癌症研究的持续兴趣，用小分子靶向 G4 已成为药物开发的理想方法。植物性膳食多酚因其显着的抗癌作用而备受关注。研究表明，多酚表现出有趣的结合 G4 的支架，可以通过稳定这些 G4 结构来有效下调原癌基因。因此，本综述不仅总结了天然膳食多酚（包括类似物）作为G4稳定剂的研究，而且揭示了其抗癌活性。此外，还讨论了 G4 多酚的结构和抗氧化见解，并提出了未来的发展。这些见解可能为开发下一代核酸靶向抗癌药物铺平道路。版权所有 © 2023。由 Elsevier B.V. 出版。

G-quadruplexes (G4s) have arrested continuous interest in cancer research, and targeting G4s with small molecules has become an ideal approach for drug development. Plant-based dietary polyphenols have attracted much attention for their remarkable anti-cancer effects. Studies have suggested that polyphenols exhibit interesting scaffolds to bind G4s, which can effectively downregulate the proto-oncogenes by stabilizing those G4 structures. Therefore, this review not only summarizes studies on natural dietary polyphenols (including analogs) as G4 stabilizers, but also reveals their anti-cancer activities. Furthermore, the structural and antioxidant insights of polyphenols with G4s are discussed, and future development is proposed. These insights may pave the way for the development of the next generation of anti-cancer drugs targeting nucleic acids.Copyright © 2023. Published by Elsevier B.V.