表观遗传学研究的快速进展为治疗多种癌症带来了新的希望。在RNA表观遗传学方面，ac4C乙酰化修饰显示出前景，而N-乙酰转移酶10发挥着广泛的生物学功能，对细胞生命事件具有重大影响，并且在许多恶性肿瘤中经常高表达。 N-乙酰转移酶 10 是一种乙酰转移酶，在细胞过程和寿命中具有重要的生物学作用。由于它在许多恶性肿瘤中高表达，因此被认为是一种促癌基因。该综述旨在介绍 NAT10，从多个角度总结 ac4C 乙酰化对肿瘤生长的影响，并讨论 NAT10 可能的治疗靶点以及 ac4C 乙酰化研究的未来方向。版权所有 © 2023。由 Elsevier B.V. 出版。

The quick progress of epigenetic study has kindled new hope for treating many cancers. When it comes to RNA epigenetics, the ac4C acetylation modification is showing promise, whereas N-acetyltransferase 10 plays a wide range of biological functions, has a significant impact on cellular life events, and is frequently highly expressed in many malignant tumors. N-acetyltransferase 10 is an acetyltransferase with important biological involvement in cellular processes and lifespan. Because it is highly expressed in many malignant tumors, it is considered a pro-carcinogenic gene. The review aims to introduce NAT10, summarize the effects of ac4C acetylation on tumor growth from multiple angles, and discuss the possible therapeutic targeting of NAT10 and the future directions of ac4C acetylation investigations.Copyright © 2023. Published by Elsevier B.V.