缺氧信号传导和转移进展。
Hypoxia signaling and metastatic progression.
发表日期：2023 Nov 03
作者：
Luana Schito, Sergio Rey-Keim
来源：
SEMINARS IN CANCER BIOLOGY
摘要：
恶性增殖过程中氧气供应和需求之间的不平衡导致氧稳态的破坏，导致缺氧肿瘤微环境的发展，从而促进与转移和患者死亡率相关的侵袭性癌细胞表型的获得。在这篇综述中，提出了肿瘤缺氧和转移进展之间的机制联系。强调了以缺氧信号通路作为阻止癌细胞转移活动的策略的现状和前景。版权所有 © 2023 作者。由爱思唯尔有限公司出版。保留所有权利。
Disruption of oxygen homeostasis, resulting from an imbalance between O2 supply and demand during malignant proliferation, leads to the development of hypoxic tumor microenvironments that promote the acquisition of aggressive cancer cell phenotypes linked to metastasis and patient mortality. In this review, the mechanistic links between tumor hypoxia and metastatic progression are presented. Current status and perspectives of targeting hypoxia signaling pathways as a strategy to halt cancer cell metastatic activities are emphasized.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.