最近的研究结果将真核翻译起始因子 eIF4E 定位为 mRNA 剪接的新型调节剂，该过程影响所得蛋白质的形式和功能。 eIF4E 与剪接体以及一些含有内含子的转录本发生物理相互作用，这意味着在一些剪接事件中具有直接作用。此外，eIF4E 推动了熔接机械关键部件的生产，从而对熔接产生更大规模的影响。这些驱动依赖于 eIF4E 的剪接签名重新编程。这项工作完成了一系列研究，证明 eIF4E 在所有主要 mRNA 成熟步骤中发挥作用，其中 eIF4E 驱动 RNA 加工机器的产生，并护送一些转录物通过各种成熟步骤。通过这种方式，eIF4E 连接了 mRNA 加工-输出-翻译轴，将核 mRNA 加工与细胞质翻译联系起来。 eIF4E 升高与急性髓系白血病患者的较差预后有关，因为这些活动失调。了解这些效应可以为转录后控制和 eIF4E 驱动的癌症提供新的见解。© 2023 作者。 BioEssays 由 Wiley periodicals LLC 出版。

Recent findings position the eukaryotic translation initiation factor eIF4E as a novel modulator of mRNA splicing, a process that impacts the form and function of resultant proteins. eIF4E physically interacts with the spliceosome and with some intron-containing transcripts implying a direct role in some splicing events. Moreover, eIF4E drives the production of key components of the splicing machinery underpinning larger scale impacts on splicing. These drive eIF4E-dependent reprogramming of the splicing signature. This work completes a series of studies demonstrating eIF4E acts in all the major mRNA maturation steps whereby eIF4E drives production of the RNA processing machinery and escorts some transcripts through various maturation steps. In this way, eIF4E couples the mRNA processing-export-translation axis linking nuclear mRNA processing to cytoplasmic translation. eIF4E elevation is linked to worse outcomes in acute myeloid leukemia patients where these activities are dysregulated. Understanding these effects provides new insight into post-transcriptional control and eIF4E-driven cancers.© 2023 The Authors. BioEssays published by Wiley Periodicals LLC.