从不平衡到损伤：活性氧在氧化应激诱发的疾病和治疗探索中的核心作用。
From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration.
发表日期：2023
作者：
Sheryar Afzal, Aimi Syamima Abdul Manap, Ali Attiq, Ibrahim Albokhadaim, Mahmoud Kandeel, Sameer M Alhojaily
来源：
Epigenetics & Chromatin
摘要：
活性氧 (ROS) 的产生和积累增加会导致各种健康问题，包括代谢问题、癌症和神经系统疾病。我们的身体通过 SOD、CAT 和 GPx 等生物抗氧化剂来抵消 ROS，这有助于防止细胞损伤。然而，如果活性氧和这些抗氧化剂之间存在不平衡，就会导致氧化应激。这可能会导致分子水平上的遗传和表观遗传变化。这篇综述深入探讨了 ROS 如何在氧化应激引起的疾病中发挥作用。我们还研究用于研究 ROS 途径的动物模型。这项研究提供了对机制、病理学、表观遗传变化和动物模型的见解，以协助药物开发和疾病理解。版权所有 © 2023 Afzal、Abdul Manap、Attiq、Albokhadaim、Kandeel 和 Alhojaily。
Increased production and buildup of reactive oxygen species (ROS) can lead to various health issues, including metabolic problems, cancers, and neurological conditions. Our bodies counteract ROS with biological antioxidants such as SOD, CAT, and GPx, which help prevent cellular damage. However, if there is an imbalance between ROS and these antioxidants, it can result in oxidative stress. This can cause genetic and epigenetic changes at the molecular level. This review delves into how ROS plays a role in disorders caused by oxidative stress. We also look at animal models used for researching ROS pathways. This study offers insights into the mechanism, pathology, epigenetic changes, and animal models to assist in drug development and disease understanding.Copyright © 2023 Afzal, Abdul Manap, Attiq, Albokhadaim, Kandeel and Alhojaily.