COVID-19 大流行导致死亡率过高，并改变了全球死亡原因的趋势。在本研究中，我们调查了 COVID-19 大流行期间（2020-2022 年）与基线（2018-2020 年）相比的全因和特定原因死亡情况，考虑了年龄组、性别、居住地和死亡地点位于伊朗东部的南呼罗珊省。本生态研究是使用 2018-2022 年南呼罗珊省死亡证明数据进行的。根据年龄组、居住地、死亡地点和性别，计算和比较了 COVID-19 之前（2018-2020 年）和期间的死亡人数以及全因和特定原因死亡率（每 10 万人）大流行（2020-2022）。我们还计算了因死亡而损失的总生命年数（YLL）和特定性别的出生时预期寿命。从2018年3月21日到2020年3月20日（大流行前），共有7,766人死亡，9,984人死亡2020年3月21日至2022年3月20日（大流行）死亡人数。 COVID-19 大流行期间，平均死亡年龄增加了约 2 岁。 20岁及以上年龄组的死亡率显着增加。超额死亡人数最多的是男性、60 岁以上、在家死亡和农村人口。 COVID-19 导致的死亡占死亡人数的近 17%。由于内分泌和心血管疾病，死亡率增幅最高。在 COVID-19 大流行期间，泌尿生殖系统和围产期某些疾病导致的死亡率有所下降。在农村和城市地区，大流行期间男女死亡的主要原因是心血管疾病、COVID-19、癌症、慢性呼吸道疾病、事故和内分泌疾病。寿命损失年数 (YLL) 增加了近 15.0%，这主要是由于 COVID-19，从 2018 年到 202 年，男女出生时的预期寿命都在稳步下降（从 78.4 岁到 75 岁）。在这项研究中，我们发现，所有在 COVID-19 大流行期间，死亡率增加了 25.5%，尤其是男性、老年人、农村居民和在家中（医院外）死亡的人。考虑到 COVID-19 大流行期间最常见的死亡原因也是非传染性疾病。即使在像COVID-19这样的严重传染病流行期间，也有必要关注非传染性疾病。 COVID-19大流行期间损失的寿命也有所增加，有必要关注所有年龄段，特别是年轻人的死因。在大多数发展中国家，这些群体的首要死因是事故。版权所有 © 2023 Pirayesh、Riahi、Bidokhti 和 Kazemi。

COVID-19 pandemic resulted in excess mortality and changed the trends of causes of death worldwide. In this study, we investigate the all-cause and cause-specific deaths during the COVID-19 pandemic (2020-2022) compared to the baseline (2018-2020), considering age groups, gender, place of residence, and place of death in south Khorasan, east of Iran.The present ecological study was conducted using South Khorasan Province death certificate data during 2018-2022. The number of death and all-cause and cause-specific mortality rates (per 100,000 people) were calculated and compared based on age groups, place of residence, place of death, and gender before (2018-2020) and during the COVID-19 pandemic (2020-2022). We also calculated total and cause-specific years of life lost (YLL) to death and gender-specific life expectancy at birth.A total of 7,766 deaths occurred from March 21, 2018, to March 20, 2020 (pre-pandemic) and 9,984 deaths from March 21, 2020, to March 20, 2022 (pandemic). The mean age at death increased by about 2 years during the COVID-19 pandemic. The mortality rate was significantly increased in the age groups 20 years and older. The most excess deaths were recorded in men, Aged more than 60 years, death at home, and the rural population. Mortality due to COVID-19 accounted for nearly 17% of deaths. The highest increase in mortality rate was observed due to endocrine and Cardiovascular diseases. Mortality rates due to the genitourinary system and Certain conditions originating in the perinatal period have decreased during the COVID-19 pandemic. The major causes of death during the pandemic were Cardiovascular diseases, COVID-19, cancer, chronic respiratory diseases, accidents, and endocrine diseases in both sexes, in rural and urban areas. Years of life lost (YLL) increased by nearly 15.0%, which was mostly due to COVID-19, life expectancy at birth has steadily declined from 2018 to202 for both genders (from 78.4 to 75).In this study, we found that All-cause mortality increased by 25.5% during the COVID-19 pandemic, especially in men, older adult, Rural residents, and those who died at home (outside the hospital). Considering that the most common causes of death during the COVID-19 pandemic are also non-communicable diseases. It is necessary to pay attention to non-communicable diseases even during the pandemic of a serious infectious disease like COVID-19. The years of life lost also increased during the COVID-19 pandemic, which is necessary to pay attention to all age groups, especially the causes of death in young people. In most developing countries, the first cause of death of these groups is accidents.Copyright © 2023 Pirayesh, Riahi, Bidokhti and Kazemi.