非黑色素瘤皮肤癌（NMSC）是一种常见的皮肤恶性肿瘤。许多研究表明，三卤甲烷 (THM) 暴露与肿瘤密切相关，但与 NMSC 无关。我们的调查旨在探讨 THM 暴露与 NMSC 之间的关联。收集了 2011 年至 2020 年国家健康和营养检查调查 (NHANES) 的横截面数据。进行泊松回归和亚组分析以评估各个 THM 成分与 NMSC 之间的关联。还使用了拟合平滑曲线和广义相加模型。这项研究涉及 5,715 人，其中 98 人（1.7%）自我报告 NMSC。调整协变量后，泊松回归显示较高的血液 TBM 水平与 NMSC 的可能性增加相关（OR = 1.03；95% CI：1.01-1.05，p = 0.002）。然而，TCM、DBCM和BDCM的血液水平与NMSC的可能性之间的相关性并不具有统计学意义（均p>0.05）。亚组分析和相互作用测试显示血液 TBM 浓度和 NMSC 可能性之间没有显着差异，表明年龄、性别和种族与这种正相关性显着独立（所有 p < 0.05）。我们的结果表明，在 65 岁以上的成年人中在美国，血液 TBM 浓度升高与 NMSC 呈正相关。需要更多的前瞻性研究来验证这种与早期预防 NMSC 的关系。版权所有 © 2023 高、郭、韩、刘、侯、王、杨和王。

Non-melanoma skin cancer (NMSC) is a prevalent skin malignancy. It has been indicated in many studies that trihalomethanes (THMs) exposure has a strong association with tumors but has not been associated with NMSC. Our investigation aims to explore the association between THMs exposure and NMSC.Cross-sectional data from the 2011 to 2020 National Health and Nutrition Examination Survey (NHANES) was collected. Poisson regression and subgroup analyses were performed to evaluate the association between individual THMs components and NMSC. Fitted smoothing curves and generalized additive models were also used.This study involved 5,715 individuals, 98 (1.7%) of whom self-reported NMSC. After adjusting for covariates, Poisson regression showed that higher blood TBM levels were associated with an increased likelihood of NMSC (OR = 1.03; 95% CI: 1.01-1.05, p = 0.002). However, the correlation between the blood levels of TCM, DBCM, and BDCM and the likelihood of NMSC was not statistically significant (all p > 0.05). Subgroup analysis and interaction tests showed no significant differences between blood TBM concentration and the likelihood of NMSC, indicating that age, gender, and race were significantly independent of this positive association (all p < 0.05).Our results implied that among adults older than 65 years old in the U.S., elevated blood TBM concentrations were positively associated with NMSC. More prospective investigations are required to validate this relationship with the early prevention of NMSC.Copyright © 2023 Gao, Guo, Han, Liu, Hou, Wang, Yang and Wang.