SRY-box 转录因子 21 反义分歧转录物 1 (SOX21-AS1) 是一种多面长非编码 RNA (lncRNA)，在肿瘤疾病和阿尔茨海默病中发挥着多种作用。其异常表达复杂地调节广泛的细胞过程，从上皮-间质转化（EMT）、细胞凋亡、迁移、转移、干性到耐药性。 SOX21-AS1 通过参与竞争性内源 RNA (ceRNA) 网络、调节下游基因以及调节关键通路（包括 PI3K/AKT、Hippo、Wnt/β-catenin 和 ERK 信号传导）来实现这些效果。 SOX21-AS1 表达与各种临床病理特征具有显着的临床相关性。此外，正如现有文献和 TCGA 泛癌分析所证明的那样，它在一系列肿瘤中表现出有希望的预后和诊断潜力。在阿尔茨海默病中，SOX21-AS1 发挥着独特的作用。它通过与 miR-107 和 miR-132 相互作用并影响 PI3K/AKT 和 Wnt 信号通路来影响神经元活力、细胞凋亡和氧化应激。这篇全面的综述揭示了 SOX21-AS1 的功能及其对肿瘤性疾病和阿尔茨海默氏病影响的调控机制。它强调了 SOX21-AS1 的临床意义，并将其定位为肿瘤学和神经退行性领域有前途的治疗靶点。© 作者。

SRY-box transcription factor 21 antisense divergent transcript 1 (SOX21-AS1) is a multifaceted long non-coding RNA (lncRNA) that plays diverse roles in both neoplastic conditions and Alzheimer's disease. Its aberrant expression intricately regulates a wide spectrum of cellular processes, spanning from epithelial-mesenchymal transition (EMT), apoptosis, migration, metastasis, and stemness to drug resistance. SOX21-AS1 achieves these effects through its involvement in the competitive endogenous RNA (ceRNA) network, modulation of downstream genes, and regulation of critical pathways, including PI3K/AKT, Hippo, Wnt/β-catenin, and ERK signaling. Of significant clinical relevance, SOX21-AS1 expression has shown robust correlations with various clinical-pathological features. Moreover, it has demonstrated promising prognostic and diagnostic potential across a spectrum of tumors, as evidenced by existing literature and TCGA pan-cancer analyses. In Alzheimer's disease, SOX21-AS1 assumes a distinctive role. It influences neuronal viability, apoptosis, and oxidative stress by interacting with miR-107 and miR-132, and affecting the PI3K/AKT and Wnt signaling pathways. This comprehensive review sheds light on the functions of SOX21-AS1 and the regulated mechanisms underpinning its impact on neoplastic conditions and Alzheimer's disease. It underscores the clinical significance of SOX21-AS1 and positions it as a promising therapeutic target in both the oncological and neurodegenerative domains.© The author(s).