三阴性乳腺癌（TNBC）是一种高度异质性乳腺肿瘤类型，具有高度恶性、侵袭性和高度复发性。铁死亡是形态学、生理学和分子水平上的一种独特的程序性细胞死亡（PCD）模式，主要特征是铁依赖性脂质过氧化物积累诱导的细胞死亡，在包括肿瘤在内的多种疾病中发挥重要作用和炎症性疾病。据报道，TNBC 细胞表现出特殊的铁和谷胱甘肽平衡代谢特征，这可能会增加 TNBC 对铁死亡的敏感性。与其他乳腺癌类型相比，TNBC 对铁死亡具有更高的敏感性。免疫细胞和肿瘤细胞之间也发生铁死亡，这表明调节铁死亡可能通过调节免疫反应来重塑 TNBC。许多铁死亡相关基因或分子具有特征性表达模式，有望成为 TNBC 的诊断靶点。此外，基于铁死亡的治疗策略，包括天然药物的分离和提取以及铁死亡诱导剂的使用，是TNBC个性化治疗的迫切需要。因此，本综述将探讨铁死亡在 TNBC 进展、诊断和治疗中的贡献，为 TNBC 的治疗提供新的视角和治疗策略。版权所有 © 2023 Li、He、Li、Xiao 和 Zhu。

Triple-negative breast cancer (TNBC) is a highly heterogeneous breast tumor type that is highly malignant, invasive, and highly recurrent. Ferroptosis is a unique mode of programmed cell death (PCD) at the morphological, physiological, and molecular levels, mainly characterized by cell death induced by iron-dependent accumulation of lipid peroxides, which plays a substantial role in a variety of diseases, including tumors and inflammatory diseases. TNBC cells have been reported to display a peculiar equilibrium metabolic profile of iron and glutathione, which may increase the sensitivity of TNBC to ferroptosis. TNBC possesses a higher sensitivity to ferroptosis than other breast cancer types. Ferroptosis also occurred between immune cells and tumor cells, suggesting that regulating ferroptosis may remodel TNBC by modulating the immune response. Many ferroptosis-related genes or molecules have characteristic expression patterns and are expected to be diagnostic targets for TNBC. Besides, therapeutic strategies based on ferroptosis, including the isolation and extraction of natural drugs and the use of ferroptosis inducers, are urgent for TNBC personalized treatment. Thus, this review will explore the contribution of ferroptosis in TNBC progression, diagnosis, and treatment, to provide novel perspectives and therapeutic strategies for TNBC management.Copyright © 2023 Li, He, Li, Xiao and Zhu.