越来越多的证据强化了 RNA 修饰在发育和疾病中的重要功能，尤其是在神经系统中。 RNA修饰影响大脑中的各种过程，包括神经发育、神经发生、神经可塑性、学习和记忆、神经再生、神经变性和脑肿瘤发生，从而导致了一个称为神经表观转录组学的新领域的出现。调节RNA修饰的机制的缺陷与一系列脑部疾病有关，从小头畸形、智力障碍、癫痫发作、精神疾病到胶质母细胞瘤等脑癌。首届 NSAS 脑表观转录组学挑战研讨会于 2023 年在瑞士克莱恩蒙塔纳举办，聚集了该领域的专家小组，讨论该领域的现状并提供新颖的转化视角。这里提供了研讨会讨论的摘要，以模拟一般神经科学领域更广泛的参与。版权所有 © 2023 Lee, Koo, Carré, Fischer, He, Kumar, Liu, Meyer, Ming, Peng, Roignant, Storkebaum, Sun, De Pietri Tonelli、Wang、Weng、Pulvirenti、Shi、Yoon 和 Song。

Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.Copyright © 2023 Lee, Koo, Carré, Fischer, He, Kumar, Liu, Meyer, Ming, Peng, Roignant, Storkebaum, Sun, De Pietri Tonelli, Wang, Weng, Pulvirenti, Shi, Yoon and Song.