我们报告一例成人造血干细胞捐献者在干细胞捐献过程中出现活动性严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染，最终移植成功完成，没有SARS-CoV-2传播。一名 34 岁女性被诊断患有急性淋巴细胞白血病，接受半倍体造血干细胞移植 (HSCT) 的报告。患者和捐赠者在移植前均接受了三剂灭活 SARS-CoV-2 疫苗。 PB-HSC是供体在感染SARS-CoV-2（轻度）过程中采集的，患者移植后未出现与SARS-CoV-2相关的症状。常规检测核酸和抗原均为阴性。在当前Omicron疫情和人群疫苗接种率较高的背景下，即使对于免疫功能低下的患者，从受感染的捐赠者那里接受PB-HSC也是可行的。这也为我们后期捐助者的选择提供了一些参考。© 2023 The Authors。

We report a case of an adult hematopoietic stem cell donor who developed active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the donation of stem cells, the final transplantation was successfully completed without SARS-CoV-2 transmission.We report on a 34-year-old female diagnosed with acute lymphoblastic leukemia who underwent hemiploid hematopoietic stem cell transplantation (HSCT). Both patient and donor received three doses of inactivated SARS-CoV-2 vaccine before transplantation. PB-HSC was collected by the donor during the process of infection with SARS-CoV-2 (mild), and the patient did not show symptoms related to SARS-CoV-2 after transplantation. Nucleic acid and antigen were negative in regular tests.In the context of the current Omicron epidemic and high vaccination rate in the population, it is feasible to receive PB-HSC from infected donors even for immunocompromised patients. This also provides some references for our later donor selection.© 2023 The Authors.