肺癌是全世界最常诊断的癌症之一。由于诊断较晚，它仍然是癌症相关死亡的主要原因。尽管它主要与吸烟有关，但最近的数据表明遗传因素最为重要。在这种情况下，对肺癌发生和进展有意义的不同过程，如内吞作用、蛋白质分泌和信号转导，是由膜筏控制的。这些高度有序的膜结构域含有小窝蛋白和弗洛林蛋白等蛋白质，这些蛋白质传统上被认为是支架蛋白，但目前在肺癌中发挥着重要作用。在这里，我们从分子角度总结了有关 Caveolins 和 Flotillins 参与肺癌的最新知识。© 作者。

Lung cancer is one of the most frequently diagnosed cancers worldwide. Due to its late diagnosis, it remains the leading cause of cancer-related deaths. Despite it is mostly associated to tobacco smoking, recent data suggested that genetic factors are of the highest importance. In this context, different processes meaningful for the development and progression of lung cancer such endocytosis, protein secretion and signal transduction, are controlled by membrane rafts. These highly ordered membrane domains contain proteins such as caveolins and flotillins, which were traditionally considered scaffold proteins but have currently been given a preponderant role in lung cancer. Here, we summarize current knowledge regarding the involvement of caveolins and flotillins in lung cancer from a molecular point of view.© The author(s).