一只 6 岁绝育的雌性贵宾犬出现下颌肿块。放射线检查显示从右下颌尖牙到第四前磨牙的骨质溶解，以及水平骨质流失和右下颌第一和第二前磨牙的背侧移位。颅锥束计算机断层扫描显示右下颌尖牙和第四前磨牙水平骨质溶解。右下颌尖牙根尖区可见破坏性骨病变，靠近下颌管的右下颌第一磨牙根间骨有大量侵犯。因此，进行了单侧全下颌骨切除术和皮瓣手术。组织病理学检查显示界限不清的浸润性肿瘤上皮细胞形成小岛和小梁。肿瘤细胞表现出细胞学异型性和高有丝分裂活性的恶性特征。此外，肿瘤性上皮细胞经常出现鬼细胞改变，被诊断为鬼细胞牙源性癌（GCOC）。对该犬进行了1年的随访，期间除了轻微的下颌漂移、舌头突出和流口水外，没有观察到严重的并发症或局部复发。本病例报告描述了狗未报告的 GCOC 的临床特征、诊断影像和组织学特征，以及手术切除后的良好结果。版权所有 © 2023 Kim、Lee、Kim、Han、Han 和 Park。

A 6 year-old spayed female Poodle presented with a mandibular mass. Radiographic examination revealed osteolysis from the right mandibular canine to the fourth premolar, along with horizontal bone loss and dorsal displacement of the right mandibular first and second premolars. Skull cone beam computed tomography revealed osteolysis at the level of the right mandibular canine and fourth premolar. A destructive bone lesion was observed in the apical area of the right mandibular canine, with mass invasion of the interradicular bone of the right mandibular first molar near the mandibular canal. Consequently, unilateral total mandibulectomy and skin flap surgery were performed. Histopathological examination revealed poorly demarcated and infiltrative neoplastic epithelial cells that formed small islands and trabeculae. Neoplastic cells exhibited the malignant features of cytological atypia and high mitotic activity. Furthermore, the neoplastic epithelial cells frequently showed ghost cell changes and were diagnosed as ghost cell odontogenic carcinoma (GCOC). The dog was followed up for 1 year, during which no severe complications or local recurrence was observed, except for slight mandibular drift, tongue protrusion, and drooling. This case report describes the clinical features, diagnostic imaging, and histologic features of an unreported GCOC in a dog and the favorable outcome following surgical resection.Copyright © 2023 Kim, Lee, Kim, Han, Han and Park.