神经淋巴瘤病（NL）是一种罕见的临床疾病，肿瘤细胞侵犯脑神经、神经根、神经丛或其他周围神经，主要发生在血液系统恶性肿瘤，主要是非霍奇金淋巴瘤（NHL）患者。原发性 NL 是血液系统恶性肿瘤的首发表现。我们报告了一位 68 岁男性，他向我们提出腰痛和双下肢背部烧灼感异常，随后左脚下垂。临床和电生理检查提示双侧腰骶神经根病累及 L2-S1 根。腰骶椎 MRI 平扫正常。 F18FDG PET CT 扫描显示 L5 和左 L3 根的吸收增加。腰骶椎对比增强 MRI 显示 L5 和左 L3 根明显梭状增厚和强化，CT 引导下左 L5 根、淋巴结和骨髓活检提示大 B 细胞淋巴瘤-生发中心细胞类型。诊断为继发于 NHL 的神经淋巴瘤病。

Neurolymphomatosis (NL) is a rare clinical disease where neoplastic cells invade the cranial nerves, roots, plexus, or other peripheral nerves in patients with hematologic malignancy mainly Non-Hodgkins Lymphoma(NHL). Primary NL occurs as the first manifestation of a hematologic malignancy. We report a 68-year male who presented to us with low backache and burning paraesthesia in the back of both lower limbs followed by a left foot drop. The clinical and electrophysiological examination was suggestive of bilateral lumbosacral radiculopathy involving L2-S1 roots. Plain MRI of the lumbosacral spine was normal. F18FDG PET CT Scan revealed increased uptake in both L5 and left L3 roots. Contrast-enhanced MRI of the lumbosacral spine showed marked fusiform thickening and enhancement of both L5 and left L3 roots CT-guided Biopsy from left L5 root, lymph node, and bone marrow was suggestive of large B cell lymphoma-germinal center cell type. The diagnosis was neurolymphomatosis secondary to NHL.