肝血管肉瘤是一种罕见的、高度侵袭性的肝脏恶性肿瘤。肝血管肉瘤的肿瘤发生在病因学和分子特性方面的研究相对较少。最近发表在《病理学杂志》上的一项研究揭示了肝血管肉瘤发病率与慢性肾病之间存在密切关联，特别是在终末期肾病中，该研究使用了台湾国家健康保险研究数据库和机构队列的人群数据。该研究还揭示了马兜铃酸暴露的突变特征的丰富，并且是首次报道在人类肉瘤中观察到这种突变特征。 © 2023 大不列颠及爱尔兰病理学会。© 2023 大不列颠及爱尔兰病理学会。

Hepatic angiosarcoma is a rare, highly aggressive malignancy of the liver. The tumorigenesis of hepatic angiosarcoma has been relatively understudied in terms of aetiology and molecular properties. A recent study published in The Journal of Pathology revealed a strong association between hepatic angiosarcoma incidence and chronic kidney disease, particularly in end-stage renal disease using population-based data from the National Health Insurance Research Database in Taiwan and an institutional cohort. The study also revealed enrichment in the mutational signature of aristolochic acid exposure and is the first reported observation of this mutational signature in human sarcomas. © 2023 The Pathological Society of Great Britain and Ireland.© 2023 The Pathological Society of Great Britain and Ireland.