妇科癌症抗肿瘤治疗后静息能量消耗的变化:一项前瞻性试点研究。
Resting energy expenditure changes after antineoplastic treatment in gynecological cancer: a prospective pilot study.
发表日期:2023 Oct 27
作者:
Karolina Alvarez-Altamirano, Karina Miramontes-Balcon, Carolina Cárcoba-Tenorio, Mónica Bejarano-Rosales, María Amanda-Casillas, Juan Alberto Serrano-Olvera, Vanessa Fuchs-Tarlovsky
来源:
PHYSICAL THERAPY & REHABILITATION JOURNAL
摘要:
癌症患者的能量代谢受到不同因素的影响。然而,抗肿瘤治疗的效果尚不清楚,特别是在女性中。在抗肿瘤治疗的第一个周期之前(T0)和之后(T1)通过间接量热法(IC)评估静息能量消耗(REE):放射治疗(RT),将化疗 (CT) 和伴随放化疗 (CRT)、生活质量 (QoL) 和 REE 的准确性与每公斤国际指南建议(欧洲临床营养和代谢学会 [ESPEN])进行比较。一项观察性纵向研究在诊断为妇科癌症并接受抗肿瘤治疗的女性中进行:RT、CT 和 CRT。测量体重减轻、实际体重和身高。 REE 在 T0-T1 中进行评估,并与 ESPEN 建议进行比较。 Kruskal-Wallis 检验和 Bland-Alman 分析分别用于确定通过体力活动 (TEE) 调整的 REE 与 ESPEN 建议的一致性(预测能量的 ± 10%)。 纳入的 54 名癌症女性:31.5% RT 组为 (n = 17),CT 组为 31.5 % (n = 17),CRT 组为 37 % (n = 20)。 REE 在总人群中显示出 T0 和 T1 之间的统计差异 (p = 0.018),但这些与抗癌治疗组无关 (p > 0.05)。治疗后生活质量没有显着变化(p > 0.05)。与 TEE 相比,25 和 30 kcal/kg 的准确度低于 30%。 妇科癌症女性的 REE 在抗肿瘤治疗后下降,但这与特定的抗肿瘤治疗无关。需要开展研究来确定 ESPEN 建议与癌症女性中通过 IC 和临床因素估计的 TEE 的准确性。
energy metabolism in cancer patients is influenced by different factors. However, the effect of antineoplastic treatment is not clear, especially in women.to evaluate resting energy expenditure (REE) by indirect calorimetry (IC) before (T0) and after (T1) first cycle period of antineoplastic therapy: radiotherapy (RT), chemotherapy (CT), and concomitant chemoradiation therapy (CRT), quality of life (QoL) and accuracy of REE were compared with international guidelines recommendations per kilogram (European Society for Clinical Nutrition and Metabolism [ESPEN]).an observational, longitudinal study was conducted in women with gynecological cancer diagnosis undergoing antineoplastic treatment: RT, CT and CRT. Weight loss, actual body weight and height were measured. REE was evaluated in T0-T1 and compared with ESPEN recommendations. Kruskal-Wallis test and Bland-Alman analysis were used to determine the agreement (± 10 % of energy predicted) of REE adjusted by physical activity (TEE) compared with ESPEN recommendations, respectively.fifty-four women with cancer were included: 31.5 % (n = 17) for RT group, 31.5 % (n = 17) for CT group and 37 % (n = 20) for CRT group. REE showed statistical differences between T0 and T1 in the total population (p = 0.018), but these were not associated with anticancer therapy groups (p > 0.05). QoL had no significant changes after treatment (p > 0.05). Accuracy of 25 and 30 kcal/kg compared to TEE was less than 30 %.REE in women with gynecological cancer decreased after antineoplastic treatments but this is not associated with a particular antineoplastic therapy. It is needed to develop research to determine the accuracy of ESPEN recommendations with TEE estimated by IC and clinical factors in women with cancer.