本研究进行了荟萃分析，以评估多酚和抗程序性细胞死亡-1（PD-1）/程序性细胞死亡配体-1（PD-L1）抑制剂的联合作用。相关研究来自电子数据库。通过Stata 15.0软件计算标准化平均差（SMD）或风险比（HR）。纳入了16项临床前研究。总体荟萃分析显示，与单独抗PD-1/PD-L1相比，多酚联合治疗显着降低了肿瘤体积（SMD = -3.28）、重量（SMD = -2.18）、数量（SMD = -2.17） ），并延长了小鼠的存活率（HR = 0.45）（所有P < 0.001）。机制研究的汇总分析表明，多酚联合治疗可以增加细胞毒性 CD8 T 细胞 (SMD = 3.88; P < 0.001)、IFN-γ CD8 T 细胞 (SMD = 2.38; P < 0.001) 的数量，减少髓系细胞的数量。衍生的抑制细胞（SMD = -2.52；P = 0.044）和Treg细胞（SMD = -4.00；P = 0.004）并抑制肿瘤中PD-L1的表达（SMD = -13.41；P < 0.001）。亚组分析表明，类姜黄素、类黄酮和二苯乙烯改变了肿瘤体积、CD8 T 细胞百分比、IFN-γ CD8 T 细胞和 PD-L1 表达。 对于抗肿瘤药物反应不佳的患者，补充多酚可能是一种有前景的联合策略。 PD-1/PD-L1单一疗法。

This study performed a meta-analysis to evaluate the combined effects of polyphenols and anti-programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors.Relevant studies were collected from electronic databases. Standardized mean differences (SMDs) or hazard ratio (HR) was calculated by Stata 15.0 software.Sixteen preclinical studies were included. The overall meta-analysis showed that, compared to anti-PD-1/PD-L1 alone, polyphenol combined therapy significantly reduced the tumor volume (SMD = -3.28), weight (SMD = -2.18), number (SMD = -2.17), and prolonged the survival (HR = 0.45) of mice (all P < 0.001). Pooled analysis of mechanism studies indicated polyphenol combined therapy could increase the number of cytotoxic CD8+ T cells (SMD = 3.88; P < 0.001), IFN-γ+ CD8+ T cells (SMD = 2.38; P < 0.001), decrease the number of myeloid-derived suppressor cells (SMD = -2.52; P = 0.044) and Treg cells (SMD = -4.00; P = 0.004) and suppress PD-L1 expression in tumors (SMD = -13.41; P < 0.001). Subgroup analyses demonstrated curcuminoids, flavonoids, and stilbene changed the tumor volume, the percentage of CD8+ T cells, IFN-γ+CD8+ T cells, and PD-L1 expression.Polyphenol supplementation may be a promising combined strategy for patients with poor response to anti-PD-1/PD-L1 monotherapy.