本研究通过饲喂雏鸡日粮，探讨太子参多糖（PHP）对雏鸡生长发育及肝脏代谢的影响。选取 7 日龄固始公鸡 400 只，随机分为 4 组，分别标记为 A、B、C、D。A 组饲喂基础日粮，B、C、D 组分别饲喂 100 mg、200 mg 和 200 mg。每公斤基础饮食分别含有 400 毫克 PHP。 14、21、28、35日龄时，每组随机抽取5只雏鸡采集样本进行指标检测。结果表明，与A组相比，14、21、28天平均日采食量（ADFI）和料重比（F/G）显着降低（P < 0.05），显着增加。 21天、28天平均日增重（ADG）显着升高（P < 0.05），总蛋白（TP）、白蛋白（ALB）、胰岛素（INS）、甲状腺素（T3）、生长激素（GH）水平显着升高14 d、28 d（P < 0.05），C组28 d葡萄糖（GLU）、总胆固醇（TC）、胰高血糖素（GC）、甘油三酯（TG）水平显着降低（P < 0.05）。 14 d、21 d TP、ALB 水平显着升高（P < 0.05），35 d TP 水平显着升高（P < 0.05），28 d GH 水平显着升高（P < 0.05）， B组和D组28天时GLU、GC水平降低（P < 0.05），14天、21天F/G显着降低（P < 0.05）。根据上述结果，选取A、C组雏鸡28 d时的肝脏进行转录组测序。测序结果显示，显着差异表达基因（SDEG）在生长发育、氧化磷酸化、PPAR信号通路和脂质代谢通路等方面富集。这些结果表明，日粮中添加200 mg/kg PHP可促进雏鸡的生长发育、脂质代谢和能量代谢，抑制炎症和肿瘤的发生，改善肝脏功能。©作者2023 . 由牛津大学出版社代表美国动物科学学会出版。版权所有。如需权限，请发送电子邮件至：journals.permissions@oup.com。

In this study, the effects of Pseudostellaria heterophylla polysaccharide (PHP) on the growth, development and liver metabolism of chicks were investigated by feeding chicks diets. Four hundred 7-day-old Gushi roosters were selected and randomly divided into four groups, labeled A, B, C and D. Group A was fed the basal diet, and Groups B, C and D were fed 100 mg, 200 mg and 400 mg PHP per kilogram of basal diet, respectively. At 14, 21, 28 and 35 days of age, five chicks were randomly selected from each group to collect samples for index detection. The results showed that compared with Group A, there were significant reduction in average daily feed intake (ADFI) and feed-to-weight ratio (F/G) at 14 d, 21 d, 28 d (P < 0.05), significant increase in average daily gain (ADG) at 21 d, 28 d (P < 0.05), significantly increased levels of total protein (TP), albumin (ALB), insulin (INS), thyroxine (T3), growth hormone (GH) at 14 d, 28 d (P < 0.05), significantly decreased levels of glucose (GLU), total cholesterol (TC), glucagon (GC), triglyceride (TG) at 28 d in Group C (P < 0.05). There were significantly increased levels of TP, ALB at 14 d, 21 d (P < 0.05), significantly increased level of TP at 35 d (P < 0.05), significantly increased level of GH at 28 d (P < 0.05), significantly decreased levels of GLU, GC at 28 d (P < 0.05), significant reduction in F/G at 14 d, 21 d in Groups B and D (P < 0.05). Based on the above results, the livers from chicks in Groups A and C at 28 d were selected for transcriptome sequencing. The sequencing results showed that significantly differentially expressed genes (SDEGs) were enriched in growth and development, oxidative phosphorylation, the PPAR signaling pathway and the lipid metabolism pathway. All these results revealedthat the addition of 200 mg/kg PHP in the diet promoted the growth and development, lipid metabolism and energy metabolism of chicks, inhibit inflammation and tumor development, and improve the function of the liver.© The Author(s) 2023. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.