DNA具有高度免疫原性，外源和内源DNA都可以分别激活病原体相关分子模式（PAMP）和危险相关分子模式（DAMP），从而激活进化上保守的cGAS-STING通路以进行炎症反应。 cGAS-STING信号通路在肿瘤疾病的发病机制和进展中发挥着非常重要的作用。对于癌症治疗，对于应该抑制还是激活 cGAS-STING 存在一些差异。失调的 cGAS-STING 信号通路可能是肿瘤的起源和发病机制，了解和调节 cGAS-STING 信号通路为癌症治疗带来了巨大的希望。在这篇综述文章中，我们讨论了 cGAS-STING 失调的分子机制，强调了 cGAS-STING 激动剂在癌症治疗中的肿瘤抑制和促进作用以及挑战。版权所有 © 2023。由 Elsevier B.V. 出版。

DNA is highly immunogenic, both exogenous and endogenous DNA can activate the pathogen-associated molecular pattern (PAMP) and danger-associated molecular pattern (DAMP), respectively, and hence activate the evolutionarily conserved cGAS-STING pathway for inflammatory responses. The cGAS-STING signaling pathway plays a very important role in the pathogenesis and progression of neoplastic diseases. For cancer therapy, there are some discrepancies on whether cGAS-STING should be inhibited or activated. Deregulated cGAS-STING signaling pathway might be the origin and pathogenesis of tumor, understanding and modulating cGAS-STING signaling holds great promise for cancer therapy. In this review article, we discuss the molecular mechanisms underlying cGAS-STING deregulation, highlighting the tumor inhibiting and promoting roles and challenges with cGAS-STING agonists in the context of cancer therapies.Copyright © 2023. Published by Elsevier B.V.