环境化学物质与氧化应激标记物的调节有关，氧化应激标记物有可能导致膀胱癌的发生。然而，关于氧化应激参数和非肌层浸润性膀胱癌（NMIBC）在治疗反应中的作用的研究有限。在这里，我们研究了 NMIBC 患者对 BCG 免疫治疗反应的氧化应激参数。总共纳入了 120 名接受 BCG 治疗的 NMIBC 患者，并根据 BCG 反应分为 2 组，其中 50 名患者为 BCG 反应组（BCG-R），50 名患者为 BCG 反应组（BCG-R），50 名患者为 BCG 反应组。 70 例为 BCG 无反应 (BCG-N)。 BCG-R 在 BCG 免疫治疗 1 年后没有肿瘤复发或进展的证据，但 BCG-N 在 BCG 滴注 3 至 6 个月周期后经膀胱镜检查确定肿瘤复发。在所有组中，我们测量了氧化应激标志物——丙二醛（MDA）、一氧化氮（NO）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的水平。 BCG-N 组的 MDA、NO 和 SOD 显着高于 BCG-R 组（P < 0.001）。此外，数据表明氧化应激标志物与 NMIBC T1 高级别和肿瘤大小 >2.5 cm 之间存在显着相关性。然而，CAT研究组之间没有发现统计学上的显着差异。研究结果表明，NMIBC的癌变与生物分子的氧化损伤有关，并表明氧化应激标志物参与了NMIBC的发生和复发。因此，确保 T1 高级别和肿瘤大小 >2.5 cm 的管理以实现抗氧化保护至关重要。版权所有 © 2023 Elsevier Inc. 保留所有权利。

Environmental chemicals have been associated with the regulation of oxidative stress markers, which have the potential for the development of bladder cancer. However, limited studies on the function of oxidative stress parameters and nonmuscle invasive bladder cancer (NMIBC) in therapy response are available. Here we studied the oxidative stress parameters in response to BCG immunotherapy in NMIBC patients.A total of 120 patients with NMIBC and treatment with BCG were enrolled and categorized into 2 groups on BCG response, 50 patients were BCG-responsive (BCG-R) and 70 were BCG-nonresponsive (BCG-N). BCG-R have no evidence of tumor recurrence or advancement after 1 year of BCG immunotherapy, but BCG-N has a recurrence of tumor after 3 to 6 months cycles of BCG instillation, as determined by cystoscopy. In all groups, we measured the levels of oxidative stress markers- malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and catalase (CAT).The levels of oxidative stress markers viz. MDA, NO, and SOD in the BCG-N group were significantly higher (P < 0.001) than in the BCG-R group. Furthermore, the data demonstrated a significant correlation between oxidative stress marker and NMIBC T1 high grade and tumor size >2.5 cm. However, no statistically significant difference was found between studied groups with CAT.The findings suggest that the carcinogenesis of NMIBC is associated with oxidative damage of biomolecules and indicates the involvement of oxidative stress markers in the development and recurrence of NMIBC.; Therefore, it is critical to ensure the management for T1 high grade and tumor size of >2.5 cm for antioxidant protection.Copyright © 2023 Elsevier Inc. All rights reserved.