选择持续一年的火星绕行任务的说明性样本任务，以强调欧洲风险评估软件在太空辐射暴露引起的癌症（所有实体癌加白血病）风险中的应用，并通过模型计算的器官剂量当量率进行量化基于辐射引起的生存率下降 (RADS) 的数量。研究发现，这次火星绕行任务中结肠所受到的辐射暴露的相关剂量在 198 至 482 毫希之间变化。这些剂量取决于性别和此处研究的其他两个因素：太阳活动阶段（最大或最小）；以及剂量当量计算中使用的空间辐射品质因数的选择。在 40 岁左右的典型宇航员年龄接受此类剂量将导致： 存活到退休年龄（65 岁）的概率降低 0.38%（95%CI：0.29；0.49）至 1.29%（95%CI） ：1.06；1.56)；退休前无癌症生存的概率降低了 0.78%（95%CI：0.59；0.99）至 2.63%（95%CI：2.16；3.18）。正如用于量化一般剂量学和辐射流行病学参数的模型特征所预期的那样，无癌生存的癌症发病风险高于生存的癌症死亡风险，女性的风险高于女性男性，并且太阳活动极小期的风险高于太阳活动极大期。版权所有 © 2023 作者。由 Elsevier GmbH 出版。保留所有权利。

An illustrative sample mission of a Mars swing-by mission lasting one calendar year was chosen to highlight the application of European risk assessment software to cancer (all solid cancer plus leukaemia) risks from radiation exposures in space quantified with organ dose equivalent rates from model calculations based on the quantity Radiation Attributed Decrease of Survival (RADS). The relevant dose equivalent to the colon for radiation exposures from this Mars swing-by mission were found to vary between 198 and 482 mSv. These doses depend on sex and the two other factors investigated here of: solar activity phase (maximum or minimum); and the choice of space radiation quality factor used in the calculations of dose equivalent. Such doses received at typical astronaut ages around 40 years old will result in: the probability of surviving until retirement age (65 years) being reduced by a range from 0.38% (95%CI: 0.29; 0.49) to 1.29% (95%CI: 1.06; 1.56); and the probability of surviving cancer free until retirement age being reduced by a range from 0.78% (95%CI: 0.59; 0.99) to 2.63% (95%CI: 2.16; 3.18). As expected from the features of the models applied to quantify the general dosimetric and radiation epidemiology parameters, the cancer incidence risks in terms of surviving cancer free, are higher than the cancer mortality risks in terms of surviving, the risks for females are higher than for males, and the risks at solar minimum are higher than at solar maximum.Copyright © 2023 The Author(s). Published by Elsevier GmbH.. All rights reserved.