基质相互作用分子1（STIM1）参与介导钙池操纵的Ca2+进入（SOCE），驱动细胞内第二信使钙离子（Ca2+）的流入，与肿瘤细胞的增殖、转移、凋亡、自噬、新陈代谢和免疫过程。 STIM1不仅在转录水平上受到NF-κB和HIF-1的调控，而且还受到miRNA的转录后修饰和泛素化降解。最近的研究表明，STIM1 或 Ca2 信号传导可以调节肿瘤细胞的凋亡、自噬、细胞焦亡和铁死亡，并且在不同的癌症中作用不同。此外，STIM1 通过影响肿瘤细胞死亡来促进抗肿瘤治疗的抵抗。进一步研究 STIM1 控制其他形式的肿瘤细胞死亡的机制可能有助于发现新的治疗靶点。此外，STIM1具有调节肿瘤微环境内免疫细胞的能力。在此，我们回顾了STIM1的基本结构、功能和调控，总结了STIM1调节肿瘤细胞死亡的信号通路，并提出了针对STIM1的抗肿瘤治疗前景。© 2023。作者。

Stromal interaction molecule 1 (STIM1) is involved in mediating the store-operated Ca2+ entry (SOCE), driving the influx of the intracellular second messenger calcium ion (Ca2+), which is closely associated with tumor cell proliferation, metastasis, apoptosis, autophagy, metabolism and immune processes. STIM1 is not only regulated at the transcriptional level by NF-κB and HIF-1, but also post-transcriptionally modified by miRNAs and degraded by ubiquitination. Recent studies have shown that STIM1 or Ca2+ signaling can regulate apoptosis, autophagy, pyroptosis, and ferroptosis in tumor cells and act discrepantly in different cancers. Furthermore, STIM1 contributes to resistance against antitumor therapy by influencing tumor cell death. Further investigation into the mechanisms through which STIM1 controls other forms of tumor cell death could aid in the discovery of novel therapeutic targets. Moreover, STIM1 has the ability to regulate immune cells within the tumor microenvironment. Here, we review the basic structure, function and regulation of STIM1, summarize the signaling pathways through which STIM1 regulates tumor cell death, and propose the prospects of antitumor therapy by targeting STIM1.© 2023. The Author(s).