认识到滤泡性淋巴瘤组被认为是非常异质性的，近年来已经描述了一组滤泡性淋巴瘤，其特征是通常弥漫性生长（不形成明显的滤泡结构）以及 CD23 在淋巴瘤细胞并且不存在经典的 BCL2 易位。进一步的特征是淋巴瘤优选腹股沟定位以及具有良好预后的局部阶段。从遗传学上来说，该淋巴瘤组的特点是 STAT6 或 SOCS1 突变率较高。ICC 分类考虑到了这一发展，引入了临时实体 CD23 阳性、BCL2 重排阴性生发中心淋巴瘤。现在必须进一步研究如何准确地定义该实体（结合形态学、免疫组织化学表型、关注遗传改变），以便为这些病例的统一分类和更好的临床特征铺平道路 - 特别是关于可能的新病例治疗方案。© 2023。作者。

Acknowledgeing that the group of follicular lymphomas is to be regarded as very heterogeneous, a group of follicular lymphomas has been delineated in recent years that was characterised by an often diffuse growth (without formation of evident follicular structures) as well as expression of CD23 in the lymphoma cells and the absence of the classic BCL2 translocation. Further characteristics are a preferred inguinal localisation of the lymphomas and a localised stage with a good prognosis. Genetically, this lymphoma group is characterised by a high rate of either STAT6 or SOCS1 mutations.The ICC classification took this development into account by introducing the provisional entity CD23 positive, BCL2 rearrangement-negative germinal centre lymphoma. Further studies must now show how exactly this entity can be defined (combination of morphology, immunohistochemical phenotype, focus on genetic alterations) in order to pave the way towards a uniform classification and a better clinical characterisation of these cases - especially with regard to possible new therapeutic treatment options.© 2023. The Author(s).