肿瘤特异性生长因子（TSGF）是一种免疫相关因子，在人类癌症的临床管理中表现良好。然而，血清TSGF在食管鳞状细胞癌（ESCC）中的作用尚未完全阐明。本研究共收集了562例食管鳞状细胞癌病例，并提供了术前诊断时血清TSGF水平的信息。采用速率法检测术前血清TSGF。我们回顾性分析其与食管鳞癌临床病理特征和生存的相关性。通过受试者工作特征（ROC）分析确定血清TSGF的临界值为60.5 U/mL。血清TSGF与性别（P < 0.001）、肿瘤部位（P = 0.022）、吸烟（P < 0.001）、饮酒（P < 0.001）、淋巴结受累（P = 0.007）和TNM分期相关（P = 0.004）。生存分析显示，血清TSGF水平高的ESCC患者预后较差（P = 0.006），特别是男性ESCC病例（P = 0.001）、60岁以下（P = 0.036）、男性中间位置患者(P = 0.023)、烟草消费(P = 0.004)、G1  G2 (P = 0.031)、晚期T分期(P = 0.033)、淋巴结受累(P = 0.003)、TNM分期(P = 0.00) 3）。单因素Cox回归分析显示吸烟、饮酒情况、肿瘤分级、T分期、淋巴结转移、TNM分期、血清TSGF水平是食管鳞癌的预后相关因素。多因素回归分析显示，吸烟史、较高的血清TSGF水平和晚期T分期会增加食管鳞癌相关死亡的风险。简而言之，血清TSGF水平与食管鳞癌的恶性特征有关。它与生存率呈正相关，但被确定为 ESCC 的独立危险因素。© 2023。作者。

Tumor-specific growth factor (TSGF) is an immune-related factor that offers good performance in the clinical management of human cancers. However, the role of serum TSGF in esophageal squamous cell carcinoma (ESCC) has not been fully clarified.A total of 562 ESCC cases were collected in our study, with available information on preoperative serum levels of TSGF at diagnosis. Preoperative serum TSGF was detected using the rate method. We retrospectively analyzed its correlation with clinicopathological features of ESCC and survival.The cut-off value of serum TSGF was determined to be 60.5 U/mL by receiver operating characteristic (ROC) analysis. Serum TSGF was associated with gender (P < 0.001), tumor location (P = 0.022), tobacco use (P < 0.001), alcohol consumption (P < 0.001), lymph node involvement (P = 0.007), and TNM staging (P = 0.004). The survival analysis revealed that ESCC patients with high levels of serum TSGF had poorer prognosis than those with high TSGF (P = 0.006), especially for male ESCC cases (P = 0.001), under 60 year (P = 0.036), male middle location (P = 0.023), tobacco consumption (P = 0.004), G1 + G2 (P = 0.031), advanced T staging (P = 0.033), lymph node involvement (P = 0.003), TNM staging (P = 0.003). Univariate Cox regression analysis indicated that exposure to smoking and drinking, tumor grade, T staging, lymph node metastasis, TNM staging, and serum TSGF level were the prognosis-related factors of ESCC. Multivariate regression analysis revealed that smoking history, higher serum TSGF levels, and advanced T stage enhanced the risk of ESCC-related death.In brief, serum TSGF levels had in relation to malignant features of ESCC. It was positively correlated with survival but was identified as an independent risk factor for ESCC.© 2023. The Author(s).