在皮肤鳞状细胞癌中，耳部（ecSCC）是最常见的部位之一。百分之六到十一的病例发现局部区域淋巴结转移，与其他部位相比，转移增加。本研究的目的是测试标记物 PD-L1、PD-1、CD4、CD8 和 FoxP3 作为预后预测标记物的适用性。本研究纳入了 64 名 ecSCC 患者。免疫组化标志物（PD-L1、PD-1、CD4、CD8、FOXP3）的表达与回顾性临床病理参数（淋巴结转移、远处转移、随访期间淋巴结转移、疾病进展、疾病特异性死亡）相关).疾病特异性死亡增加与 Foxp3 减弱 (p = 0.003) 或 CD8 减少 (p = 0.04) 之间存在相关性。 39.1% 的患者中发现 PD-L1 表达≥1%。所研究的标记物（CD4、CD8、FoxP3、PD-1、PD-L1）总体上似乎不太适合 ecSCC 的预后评估。只有疾病特异性死亡与 CD8 或 FoxP3 的相关性似乎才值得在更大的集体中进行测试。© 2023。作者。

Among cutaneous squamous cell carcinomas, the ear (ecSCC) is one of the most common sites. Loco regional lymph node metastasis is found in six to eleven percent of cases, corresponding to increased metastasis compared to other sites. The aim of this study was to test the markers PD-L1, PD-1, CD4, CD8, and FoxP3 for suitability as prognostic predictive markers.Sixty-four patients with ecSCC were included in this study. The expression of immunohistochemical markers (PD-L1, PD-1, CD4, CD8, FOXP3) was correlated with retrospective clinic pathological parameters (lymph node metastasis, distant metastasis, lymph node metastasis during follow-up, disease progression, disease-specific death).There was a correlation between increased disease specific death and a weak Foxp3 (p = 0.003) or reduced CD8 (p = 0.04). A PD-L1 expression > 1% was found in 39.1% of patients.The investigated markers (CD4, CD8, FoxP3, PD-1, PD-L1) seem overall rather inappropriate for prognostic evaluation in ecSCC. Only the correlation of disease specific death with CD8 or FoxP3 seems to be worth testing in larger collectives.© 2023. The Author(s).