我们的研究旨在调查心肌梗死后心脏氧化应激与炎症细胞因子反应之间的潜在相关性。共纳入120例在我院接受经皮冠状动脉介入治疗（PCI）的急性心肌梗死患者。分析其一般临床资料，并比较炎症因子、氧化应激标志物、心泵功能和心功能的水平。使用皮尔逊线性相关性评估心脏氧化应激和炎症细胞因子反应之间的相关性。治疗后，血清皮质醇、促甲状腺激素 (TSH)、B 型利尿钠肽 (BNP)、C 反应蛋白 (CRP)、信号转导子和转录激活子 3 (STAT3) 的血清水平显着降低。与治疗前水平相比，白细胞介素 6 (IL-6)、白细胞介素 8 (IL-8)、肿瘤坏死因子 (TNF) 和过氧化氢酶 (CAT) 水平。相反，生长激素（GH）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、总抗氧化能力（T-AOC）、心输出量（CO）和心脏指数（CI）的水平显着升高。血清皮质醇（r = 0.481，P = .001），BNP（r = 0.437，P = .001），CRP（r = 0.542，P = .001），STAT3（r = 0.835，P = ） .001), 促甲状腺激素(P = .001)、IL-8 (r = 0.867, P = .001)、TNF-α (r = 0.439, P = .001) 和心脏氧化应激呈显着正相关 (P < .05)。此外，GH（r = -0.654，P = .001）与免疫平衡之间存在显着负相关（P < .05）。本研究使用CO和CI等指标评估心肌梗死的严重程度。这项研究发现心肌梗塞后心脏氧化应激和炎症细胞因子之间存在显着相关性，表明它们有可能作为心肌梗塞严重程度的预测因子。

Our study was conducted to investigate the potential correlation between cardiac oxidative stress and inflammatory cytokine response following myocardial infarction. A total of 120 patients harboring acute myocardial infarction who underwent percutaneous coronary intervention (PCI) at our hospital were included. Their general clinical data were analyzed, and comparisons were made regarding the levels of inflammatory factors, oxidative stress markers, heart pump function, and cardiac function. The correlation between cardiac oxidative stress and inflammatory cytokine response was assessed using Pearson's linear correlation. Following treatment, significant reductions were seen in the serum levels of cortisol, thyroid-stimulating hormone (TSH), B-type natriuretic peptide (BNP), C-reactive protein (CRP), signal transducer and activator of transcription 3 (STAT3), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor (TNF), and catalase (CAT) compared to pre-treatment levels. Conversely, the levels of growth hormone (GH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), cardiac output (CO), and cardiac index (CI) were significantly elevated. Serum cortisol (r = 0.481, P = .001), BNP (r = 0.437, P = .001), CRP (r = 0.542, P = .001), STAT3 (r = 0.835, P = .001), TSH (P = .001), IL-8 (r = 0.867, P = .001), TNF-α (r = 0.439, P = .001), and cardiac oxidative stress demonstrated significantly positive correlations (P < .05). Additionally, a significant negative correlation was found between GH (r = -0.654, P = .001) and immune balance (P < .05). This study evaluated the severity of myocardial infarction using indicators such as CO and CI. This study found a significant correlation between cardiac oxidative stress and inflammatory cytokines after myocardial infarction, suggesting their potential as predictors of myocardial infarction severity.