蜂胶及其主要酚类化合物咖啡酸苯乙酯 (CAPE) 由于其抗炎特性和潜在的治疗应用而引起了相当大的科学兴趣。这篇叙述性综述探讨了 CAPE 在癌症治疗中的潜在效用。我们全面回顾了相关研究来自 2000 年至 2022 年的科学数据库（PubMed 和 Web of Science）。我们的搜索重点是癌症、天然药物、咖啡酸苯乙酯、CAPE、癌细胞系、抗肿瘤作用和蜂胶等关键词。CAPE 表现出多种生物益处，包括抗菌、抗氧化、抗病毒、抗炎、细胞毒性和潜在的抗癌特性。大量研究已证明其对多种癌细胞系具有广泛的抗肿瘤作用，包括生长抑制、诱导细胞凋亡、预防肿瘤侵袭、抑制恶性肿瘤和抗血管生成活性。在全面的临床前毒性评估后，通过以下方法进一步评估 CAPE 的有效性和安全性：强烈建议进行临床试验来阐明其对多种人类癌症的潜在健康益处。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Propolis and its major phenolic compound, caffeic acid phenethyl ester (CAPE), have garnered considerable scientific interest due to their anti-inflammatory properties and potential therapeutic applications.This narrative review explores the potential utility of CAPE in cancer treatment.We comprehensively reviewed relevant studies from scientific databases (PubMed and Web of Science) from 2000 to 2022. Our search focused on keywords such as cancer, natural drugs, caffeic acid phenethyl ester, CAPE, cancer cell lines, antitumor effects, and propolis.CAPE exhibits diverse biological benefits, including antimicrobial, antioxidant, antiviral, anti-inflammatory, cytotoxic, and potentially anti-carcinogenic properties. Numerous studies have demonstrated its wide-ranging antitumor effects on various cancer cell lines, including growth inhibition, apoptosis induction, tumor invasiveness prevention, malignancy suppression, and anti-angiogenic activity.Following comprehensive preclinical toxicity assessments, further evaluation of CAPE's efficacy and safety through clinical trials is highly recommended to elucidate its potential health benefits in diverse forms of human cancer.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.