乳腺癌骨转移会导致严重的癌症相关疼痛，从而显着降低患者的生活质量并促进癌症进展。然而，由于对多种癌症病灶的药物输送效率差以及对癌症相关疼痛的处理不当，使用纳米医学的有效治疗仍然是一个艰巨的挑战。在这项研究中，我们利用工程巨噬细胞膜（EMM）和载药纳米颗粒，构建了一个仿生纳米平台（EMM@DJHAD），用于同步治疗骨转移性乳腺癌和相关疼痛。继承自 EMM 的肿瘤趋向性为原发性和转移性病变提供了靶向能力。随后，地西他滨和 JTC801 的协同组合增强了溶解和炎症反应，并具有杀伤作用，将肿瘤转变为 EMM 的理想诱饵，导致部队向肿瘤迁移的时间延长。 EMM@DJHAD 通过抑制骨转移小鼠模型中的 µ-阿片受体，发挥显着的肿瘤抑制作用和显着的镇痛作用。此外，纳米平台显着降低了化疗药物引起的严重毒性。总体而言，这种具有良好生物相容性的仿生纳米平台可用于有效治疗乳腺癌骨转移。© 2023 作者。河南大学和约翰·威利出版的《探索》

Breast cancer with bone metastasis accounts for serious cancer-associated pain which significantly reduces the quality of life of affected patients and promotes cancer progression. However, effective treatment using nanomedicine remains a formidable challenge owing to poor drug delivery efficiency to multiple cancer lesions and inappropriate management of cancer-associated pain. In this study, using engineered macrophage membrane (EMM) and drugs loaded nanoparticle, we constructed a biomimetic nanoplatform (EMM@DJHAD) for the concurrent therapy of bone metastatic breast cancer and associated pain. Tumor tropism inherited from EMM provided the targeting ability for both primary and metastatic lesions. Subsequently, the synergistic combination of decitabine and JTC801 boosted the lytic and inflammatory responses accompanied by a tumoricidal effect, which transformed the tumor into an ideal decoy for EMM, resulting in prolonged troop migration toward tumors. EMM@DJHAD exerted significant effects on tumor suppression and a pronounced analgesic effect by inhibiting µ-opioid receptors in bone metastasis mouse models. Moreover, the nanoplatform significantly reduced the severe toxicity induced by chemotherapy agents. Overall, this biomimetic nanoplatform with good biocompatibility may be used for the effective treatment of breast cancer with bone metastasis.© 2023 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd.