背景：胃癌是全世界癌症相关死亡的主要原因，因此发现新的治疗药物对于提高治疗效果至关重要。姜黄素是姜黄 (Curcuma longa) 中发现的一种多酚化合物，由于其抗癌特性，已在多种癌症类型中显示出潜力。本研究旨在探讨姜黄素对胃癌细胞生长、迁移和侵袭的影响，及其对磷酸肌醇3激酶（PI3K）信号级联的影响。方法：将胃癌细胞系暴露于不同浓度的姜黄素中，然后评估细胞活力、迁移和侵袭。此外，使用逆转录聚合酶链式反应 (RT-PCR) 和蛋白质印迹分析评估与 PI3K 信号级联相关的基因和蛋白质表达水平。结果：研究结果表明，用姜黄素处理的胃癌细胞的细胞活力、迁移和侵袭呈剂量依赖性下降。此外，姜黄素的施用导致 PI3K 信号传导过程中关键基因和蛋白质的下调，例如 PI3K、Akt 和 mTOR。结论：这些研究结果表明，姜黄素可能通过抑制 PI3K 信号通路发挥其对胃癌细胞的抗癌作用。这项研究的结果支持姜黄素作为胃癌治疗剂的潜力，并鼓励进一步探索其潜在的分子机制和体内有效性。© 作者 2023。

Background: Gastric cancer stands as a primary cause of cancer-related deaths worldwide, making the discovery of new therapeutic agents essential for enhancing treatment outcomes. Curcumin, a polyphenolic compound found in turmeric (Curcuma longa), has demonstrated potential in multiple cancer types due to its anti-cancer characteristics. This research aimed to examine the impact of curcumin on gastric cancer cell growth, migration, and invasion, as well as its influence on the phosphoinositide 3-kinase (PI3K) signaling cascade. Methods: Gastric cancer cell lines were exposed to varying curcumin concentrations, followed by assessments of cell viability, migration, and invasion. Furthermore, gene and protein expression levels associated with the PI3K signaling cascade were evaluated using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis. Results: The findings revealed a dose-dependent decrease in cell viability, migration, and invasion in gastric cancer cells treated with curcumin. Additionally, curcumin administration led to the downregulation of key genes and proteins within the PI3K signaling process, such as PI3K, Akt, and mTOR. Conclusion: These findings propose that curcumin may exercise its anti-cancer effects on gastric cancer cells, partly by suppressing the PI3K signaling pathway. This study's outcomes support curcumin's potential as a therapeutic agent for gastric cancer and encourage further exploration of its underlying molecular mechanisms and in vivo effectiveness.© The Author(s) 2023.