背景结直肠癌（CRC）是一个全球性的健康问题，发病率不断上升。本研究分析了影响约旦 CRC 患者总生存期 (OS) 和无病生存期 (DFS) 的人口统计学和临床​​病理因素。方法 这项回顾性、单中心研究收集了 2018 年 1 月至 2020 年 6 月在约旦皇家医疗服务中心的 CRC 患者的数据。患者变量包括疾病分期、分期风险、肿瘤位置、化疗史和转移状态。 OS 和 DFS 定义为从手术到死亡、最后一次随访或确认转移的时间。 Kaplan-Meier曲线和Cox模型用于生存分析。结果 127例CRC患者中，33.3%在随访期间死亡。大多数患者为男性（55.1%），诊断为III期（55.9%），并被归类为高风险（59.2%）。 24.4%发生转移，65.4%接受化疗。随访一年、两年和年底的 OS 分别为 85.2%、75.6% 和 66.9%。无转移率分别为 85%、78.5% 和 71%。多变量分析显示，III 期（风险比 (HR) = 2.968）和高风险期（HR = 2.966）与较短的 OS 和增加的转移风险相关。右侧肿瘤 (HR = 2.183) 的 OS 较短，而化疗接受者 (HR = 0.430) 的 OS 较长。 III 期和高风险阶段是死亡率的强预测因子，而只有 III 期和高风险阶段是转移的强预测因子。人口统计变量（性别和年龄）与生存结果没有显着相关性。结论 我们的研究结果强调了疾病分期、分期风险、肿瘤位置和化疗对约旦患者 CRC 生存的预后意义。了解这些因素可以指导量身定制的治疗并改善结果。版权所有 © 2023，Alkader 等人。

Background Colorectal cancer (CRC) is a global health concern with rising incidence. This study analyzed demographic and clinicopathological factors influencing overall survival (OS) and disease-free survival (DFS) in Jordanian CRC patients. Methodology This retrospective, single-center study collected data from CRC patients at the Royal Medical Services, Jordan, from January 2018 to June 2020. Patient variables included disease stage, stage risk, tumor location, history of chemotherapy, and metastasis status. OS and DFS were defined as the time from surgery to death, last follow-up, or metastasis confirmation. Kaplan-Meier curves and Cox models were used for survival analysis. Results Of 127 CRC patients, 33.3% died during the follow-up period. Most patients were males (55.1%), diagnosed with stage III (55.9%), and classified as high risk (59.2%). Metastasis occurred in 24.4%, and 65.4% received chemotherapy. OS at one, two, and end of the follow-up years was 85.2%, 75.6%, and 66.9%, respectively. Metastasis-free rates were 85%, 78.5%, and 71%, respectively. Multivariate analysis showed that stage III (hazard ratio (HR) = 2.968) and high-risk stage (HR = 2.966) were associated with shorter OS and increased metastasis risk. Right-sided tumors (HR = 2.183) had shorter OS, while chemotherapy recipients (HR = 0.430) had longer OS. Stage III and high-risk stages were strong predictors of mortality, while only stage III and high-risk stages were robust predictors of metastasis. Demographic variables (sex and age) showed no significant associations with survival outcomes. Conclusions Our findings highlight the prognostic significance of disease stage, stage risk, tumor location, and chemotherapy in CRC survival among Jordanian patients. Understanding these factors can guide tailored treatment and improve outcomes.Copyright © 2023, Alkader et al.