从海生海绵 Callyspongia sp. 中分离出两种新的生物碱，Aspera chaetominines A (1) 和 B (2)、一种新的土曲霉衍生物 (3)，以及 11 种已知化合物 (4-14)。衍生真菌Aspergillus versicolor SCSIO XWS04 F52，根据形态学和ITS序列分析对其进行鉴定。 1-3的平面结构通过光谱（1H、13C NMR、HSQC、HMBC和1H-1H COSY）和MS分析确定。化合物 1 和 2 对白血病 K562 和结肠癌细胞 SW1116 显示出细胞毒活性，IC50 为 7.5 至 12.5 μM，并且化合物 1 和 2 对 MDCK 细胞中 H1N1 病毒诱导的细胞致病性也显示出显着的保护作用，IC50 值分别为 15.5 和 24.5 μM 。

Two new alkaloids, Aspera chaetominines A (1) and B (2), a new derivative (3) of terrein, and together with 11 known compounds (4-14) were isolated from marine sponge Callyspongia sp. -derived fungus Aspergillus versicolour SCSIO XWS04 F52, which was identified on the basis of morphology and ITS sequence analysis. The planar structures of 1-3 were determined by spectroscopic (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), and MS analysis. Compounds 1 and 2 showed cytotoxic activity against leukaemia K562 and colon cancer cells SW1116 with IC50 7.5 to 12.5 μM, and also compounds 1 and 2 exhibited significant protection against H1N1 virus-induced cytopathogenicity in MDCK cells with IC50 values of 15.5 and 24.5 μM, respectively.