饮食相关维生素和淋巴瘤风险结果的观察性研究不一致。我们的研究旨在通过孟德尔随机化 (MR) 研究来估计膳食维生素摄入量与淋巴瘤之间的因果关系。我们将与饮食相关的视黄醇、维生素 C、维生素 E、维生素 B6 和维生素 B12 作为感兴趣的暴露，以霍奇金淋巴瘤 (HL) 和非霍奇金淋巴瘤 (NHL) 作为结果。使用逆方差加权 (IVW)、MR-Egger 回归分析和加权中位数估计因果效应，并辅以敏感性分析。结果显示，基因预测膳食维生素 B12 摄入量与降低 HL 风险相关（OR = 0.22，95% CI 0.05-0.91，p = 0.036）。 Q 检验未揭示异质性，MR-Egger 检验未显示显着截距，留一分析 (LOO) 分析未发现任何影响结果的 SNP。没有观察到膳食维生素摄入量与 NHL 风险之间存在因果关系。

Observational studies of diet-related vitamins and lymphoma risk results were inconsistent. Our study aimed to estimate the causality between dietary vitamin intake and lymphoma through a Mendelian randomisation (MR) study. We enrolled dietary-related retinol, vitamin C, vitamin E, vitamin B6 and vitamin B12 as exposures of interest, with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) as the outcome. The causal effects were estimated using inverse variance weighting (IVW), MR-Egger regression analysis and weighted median, supplemented by sensitivity analyses. The results revealed that genetically predicted dietary vitamin B12 intake was associated with a reduced HL risk (OR = 0.22, 95% CI 0.05-0.91, p = 0.036). The Q test did not reveal heterogeneity, the MR-Egger test showed no significant intercepts, and the leave-one-out (LOO) analysis did not discover any SNP that affect the results. No causal relationship about dietary vitamin intake on the NHL risk was observed.