衰老研究取得了显着进展；科学家现在能够确定减缓生物衰老过程（即“衰老标志”）的干预措施，从而延缓多种疾病（包括口腔疾病）的发病和进展。本出版物总结了 2023 年美国牙科、口腔和颅面研究协会会议期间举行的三部分会议“老年科学：衰老和口腔健康研究”期间所做的演讲。演讲者的主题涵盖转化研究领域。第 1 场概述了老年科学和健康跨度（终生无疾病和功能健康）概念。讨论了口腔癌和衰老之间的共同分子机制，并提出了研究表明牙周微生物区系是阿尔茨海默病进展的潜在因素。第二场会议重点讨论衰老的行为和社会科学方面及其口腔健康的意义。主题演讲提供的证据表明孤独和孤立会对健康产生重大影响。这些社会条件，加上口腔健康状况不佳、牙齿脱落和认知能力下降，可能会影响老年人的健康饮食能力和全身健康。研究可以帮助阐明连接这些看似不同的条件的方向和途径。第三场会议重点讨论了不同环境中口腔护理的提供以及老年人获得护理所面临的许多障碍。需要进行研究来确定和实施有效的技术和策略，以改善获得牙科护理的机会，包括新的交付和融资机制、劳动力模式、跨专业提供者教育和实践，以及电子健康记录医疗牙科整合大数据的使用。必须在从生物途径到健康社会决定因素和卫生政策的各个层面上解决改善“口腔健康跨度”、减少口腔健康差异和提高健康公平性的研究。

Research in aging has significantly advanced; scientists are now able to identify interventions that slow the biologic aging processes (i.e., the "hallmarks of aging"), thus delaying the onset and progression of multiple diseases, including oral conditions. Presentations given during the 3-part session "Geroscience: Aging and Oral Health Research," held during the 2023 American Association for Dental, Oral, and Craniofacial Research meeting, are summarized in this publication. Speakers' topics spanned the translational research spectrum. Session 1 provided an overview of the geroscience and health span (disease-free and functional health throughout life) concepts. The common molecular mechanisms between oral cancer and aging were discussed, and research was presented that showed periodontal microflora as a potential factor in Alzheimer's disease progression. Session 2 focused on behavioral and social science aspects of aging and their oral health significance. The keynote provided evidence that loneliness and isolation can have major health effects. These social conditions, along with poor oral health, tooth loss, and cognitive decline, could potentially affect healthy eating ability and systemic health in older adults. Research could help elucidate the directions and pathways connecting these seemingly disparate conditions. Session 3 focused on the delivery of oral care in different settings and the many barriers to access care faced by older adults. Research is needed to identify and implement effective technology and strategies to improve access to dental care, including new delivery and financing mechanisms, workforce models, interprofessional provider education and practice, and use of big data from medical-dental integration of electronic health records. Research to improve the "oral health span," reduce oral health disparities, and increase health equity must be tackled at all levels from biologic pathways to social determinants of health and health policies.