阿尔茨海默病（AD）是一种发生在老年和衰老前期的中枢神经系统神经退行性疾病，其特征是进行性认知功能障碍和行为障碍。 Salidroside (Sal) 是一种主要从红景天属植物中分离得到的苯丙素类化合物，具有多种药理作用。然而，Sal的确切抗AD机制尚未明确阐明。本荟萃分析旨在通过评估行为指标和生化特征来研究 Sal 发挥抗 AD 作用的可能机制。总共纳入了 20 项研究，结果表明 Sal 治疗显着改善 AD 动物模型的行为异常。在神经生化指标方面，Sal治疗可有效增加抗氧化酶超氧化物歧化酶，降低氧化应激指标丙二醛，降低炎症指标白细胞介素1β、白细胞介素6和肿瘤坏死因子α。 Sal治疗可有效降低神经病理指标，例如淀粉样蛋白-β水平和凋亡细胞数量。当将治疗啮齿类AD模型的相关文献与Sal结合时，Sal通过多种机制的治疗潜力得到了证实。但未来还需要通过更高质量的研究、更大的样本量和更全面的临床试验结果评估来进一步证实。

Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that occurs in old age and pre-aging, characterized by progressive cognitive dysfunction and behavioral impairment. Salidroside (Sal) is a phenylpropanoid mainly isolated from Rhodiola species with various pharmacological effects. However, the exact anti-AD mechanism of Sal has not been clearly elucidated. This meta-analysis aims to investigate the possible mechanisms by which Sal exerts its anti-AD effects by evaluating behavioral indicators and biochemical characteristics. A total of 20 studies were included, and the results showed that the Sal treatment significantly improved behavior abnormalities in AD animal models. With regard to neurobiochemical indicators, Sal treatment could effectively increase the antioxidant enzyme superoxide dismutase, decrease the oxidative stress indicator malondialdehyde, and decrease the inflammatory indicators interleukin 1β, interleukin 6, and tumor necrosis factor α. Sal treatment was effective in reducing neuropathological indicators, such as amyloid-β levels and the number of apoptotic cells. When the relevant literature on the treatment of rodent AD models is combined with Sal, the therapeutic potential of Sal through multiple mechanisms was confirmed. However, further confirmation by higher quality studies, larger sample sizes, and more comprehensive outcome evaluations in clinical trials is needed in the future.