铁死亡是一种新发现的调节性细胞死亡形式，其特征是过度的铁依赖性脂质过氧化。近十年来，人们对铁死亡的特征和调控机制的认识取得了重大突破，并证实铁死亡在肿瘤、炎症、神经退行性疾病、感染性疾病等多种疾病的病理生理过程中发挥着关键作用。 。胰腺是人体第二大消化腺，兼具内分泌和外分泌功能，是控制消化和新陈代谢的重要器官。近年来大量研究证实铁死亡与胰腺疾病密切相关，其原因是铁的异常积累，铁死亡是铁死亡的一个重要的生化特征，常存在于各种胰腺外分泌和内分泌疾病的病理过程中，且易受损害。胰腺受到氧化应激刺激和损伤。因此，了解胰腺疾病中铁死亡的调节机制可能为治疗策略提供有价值的新见解。在这篇综述中，我们首先总结了铁死亡的标志性特征，然后分析了铁死亡在多个层面和环节被精确调控的具体机制，包括铁代谢、脂质代谢、GPX4介导的铁死亡防御系统、GPX4非依赖性铁死亡的机制。防御系统以及自噬对铁死亡的调节。最后，我们讨论了铁死亡在胰腺疾病发生和发展中的作用，并总结了铁死亡作为胰腺疾病治疗靶点的可行性和局限性。© 2023。作者，获得 Springer-Verlag GmbH 德国独家许可，施普林格自然的一部分。

Ferroptosis is a newly discovered form of regulatory cell death characterized by excessive iron-dependent lipid peroxidation. In the past decade, significant breakthroughs have been made in comprehending the features and regulatory mechanisms of ferroptosis, and it has been confirmed that ferroptosis plays a pivotal role in the pathophysiological processes of various diseases, including tumors, inflammation, neurodegenerative diseases, and infectious diseases. The pancreas, which is the second largest digestive gland in the human body and has both endocrine and exocrine functions, is a vital organ for controlling digestion and metabolism. In recent years, numerous studies have confirmed that ferroptosis is closely related to pancreatic diseases, which is attributed to abnormal iron accumulation, as an essential biochemical feature of ferroptosis, is often present in the pathological processes of various pancreatic exocrine and endocrine diseases and the vulnerability of the pancreas to oxidative stress stimulation and damage. Therefore, comprehending the regulatory mechanism of ferroptosis in pancreatic diseases may provide valuable new insights into treatment strategies. In this review, we first summarize the hallmark features of ferroptosis and then analyze the exact mechanisms by which ferroptosis is precisely regulated at multiple levels and links, including iron metabolism, lipid metabolism, the GPX4-mediated ferroptosis defense system, the GPX4-independent ferroptosis defense system, and the regulation of autophagy on ferroptosis. Finally, we discuss the role of ferroptosis in the occurrence and development of pancreatic diseases and summarize the feasibility and limitations of ferroptosis as a therapeutic target for pancreatic diseases.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.